鼻咽癌实验动物模型的研究进展  

Research progress in experimental animal models of nasopharyngeal carcinoma

作　　者：肖洋洋 卿吉琳[3] 李宝绚 陈柳燕 陈治中[1] XIAO Yangyang;QING Jilin;LI Baoxuan;CHEN Liuyan;CHEN Zhizhong(Department of Clinical Laboratory, People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Graduate Department,Guangxi University of Chinese Medicine, Nanning 530200;Department of Obstetrics and Gynecology,Center for Reproductive Medicine and Genetics,People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021;Department of Ophthalmology,Binzhou Medical University Hospital,Binzhou 256603)

机构地区：[1]广西壮族自治区人民医院检验科,南宁530021 [2]广西中医药大学研究生院,南宁530200 [3]广西壮族自治区人民医院生殖医学中心,南宁530021 [4]滨州医学院附属医院眼科,山东滨州256603

出　　处：《中国比较医学杂志》2018年第12期108-112,共5页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81260007);广西自然科学基金(2017GXNSFAA198074)

摘　　要：鼻咽癌是我国最常见的头颈部恶性肿瘤之一,尤其是东南沿海两广,香港等地区发病率很高。并且因鼻咽癌发病位置的隐蔽性,故发现时多为中晚期,如何早发现,早治疗是困扰临床医生的难题。实验动物为鼻咽癌发病机制及治疗措施的研究提供了很好的模型。本文对经典鼻咽癌动物模型的建立及近期鼻咽癌动物模型的研究进展进行了综述,以期为鼻咽癌的研究和成果临床转化提供依据。Nasopharyngeal carcinoma is one of the most common malignancies of the head and neck in China.In particular,there is a high incidence in Guangdong and Guangxi,Hong Kong,and the southeast coast of China.Because of the inconspicuous location of nasopharyngeal cancer,it is mostly detected at mid-and late-stages.Early detection and treatment of this tumor are difficult for clinicians.Experimental animals provide a good model to study the pathogenesis and therapeutic measures of nasopharyngeal carcinoma.This article reviews the establishment of animal models of classical nasopharyngeal carcinoma and the recent research progress in animal models of nasopharyngeal carcinoma to provide a basis for research of human nasopharyngeal carcinoma and the translation of new research findings into clinical application.

关 键 词：鼻咽癌 实验动物模型 研究进展 

分 类 号：R-33[医药卫生]