奥拉西坦辅助常规治疗脑梗死患者认知功能障碍的效果  

Effect of Oxiracetam-assisted conventional treatment of cognitive dysfunction in patients with cerebral infarction

作　　者：刘春霞 LIU Chun-xia(Department of Rehabilitation Medicine,Central People′s Hospital in Huizhou City,Guangdong Province,Huizhou516000,China)

机构地区：[1]广东省惠州市中心人民医院康复医学科,广东惠州516000

出　　处：《中国当代医药》2018年第34期95-98,共4页China Modern Medicine

摘　　要：目的探讨奥拉西坦辅助常规治疗脑梗死患者认知功能障碍的效果。方法选取2017年1月～2018年1月我院收治的60例脑梗死患者作为研究对象,按照随机数字表法将其分为对照组(30例)和观察组(30例)。对照组患者给予常规治疗,观察组患者在常规治疗的基础上给予奥拉西坦辅助治疗。治疗2个月后,比较两组患者治疗前后的简易精神状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、日常生活活动能力量表(ADL)评分及治疗总有效率,并观察患者治疗前后心电图、尿常规及肝肾功能。结果两组患者治疗前的MMSE、ADL评分比较,差异无统计学意义(P>0.05);两组患者治疗后的MMSE、ADL评分均高于治疗前,且观察组患者治疗后的MMSE、ADL评分均高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前的注意力、记忆力、地点定向、时间定向、语言、视空间、执行能力评分及MoCA总分比较,差异无统计学意义(P>0.05);两组患者治疗后的注意力、记忆力、地点定向、时间定向、语言、视空间、执行能力评分及MoCA总评分高于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的注意力、记忆力、地点定向、时间定向、执行能力评分及MoCA总分均高于对照组,差异有统计学意义(P<0.05)。观察组患者的治疗总有效率(90.00%)高于对照组(66.67%),差异有统计学意义(P<0.05)。两组患者均未发生严重不良反应,且治疗期间的心电图、尿常规及肝肾功能未见异常。结论奥拉西坦辅助常规治疗脑梗死患者认知功能障碍的效果高于常规治疗。Objective To explore the effect of Oxiracetam-assisted conventional treatment of cognitive dysfunction in patients with cerebral infarction.Methods Altogether 60 patients with cerebral infarction admitted to our hospital from January 2017 to January 2018 were selected as objects and divided into the control group(30 cases)and the observation group(30 cases)according to the random number table method.The control group was given conventional treatment,and patients in the observation group were given adjunctive therapy with Oxiracetam on the basis of the conventional treatment.After 2 months of treatment,the scale scores of mini-mental state examination(MMSE),Montreal cognitive assessment(MoCA),and activity of daily living(ADL)were compared before and after treatment.The total effective rate of treatment between the two groups was compared.The electrocardiogram,urine routine and liver and kidney function were observed before and after treatment.Results There were no statistically significant differences in scores of MMSE and ADL between the two groups before treatment(P>0.05).The scores of MMSE and ADL after treatment in the two groups were higher than those before treatment,the scores of MMSE and ADL after treatment in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in scores of attention,memory,location orientation,time orientation,language,visual space,executive ability,and total MoCA scores between the two groups before treatment(P>0.05).The scores of attention,memory,location orientation,time orientation,language,visual space,executive ability and total MoCA after treatment in the two groups were higher than those before treatment,and the differences were statistically significant(P<0.05).The scores of attention,memory,location orientation,time orientation,executive ability,and total MoCA scores after treatment in the observation group were higher than those in the control group,and the differences

关 键 词：奥拉西坦 脑梗死 认知功能障碍 简易精神状态检查量表 蒙特利尔认知评估量表 日常生活活动能力量表 

分 类 号：R743.33[医药卫生—神经病学与精神病学]