B7-H4和B7-H6在卵巢癌中的表达及意义  

Expressiones of B7-H4 and B7-H6 in ovarian cancers and its clinical implication

作　　者：章晓洁 李怀芳[2] 初磊[2] 程允 梅丽艳[1] 周士华[1] ZHANG Xiao-jie;LI Huai-fang;CHU Lei;CHENG Yun;MEI Li-yan;ZHOU Shi-hua(Department of Obstetrics and Gynecology, Luodian Hospital of Baoshan District, Shanghai 201908, China;Department of Obstetrics and Gynecology, Tongji Hospital Affiated to Tongji University, Shanghai 200065, China;Department of Gynecology, Nanjing Hospital Affiated to Nanjing Medical University, Nanjing 210029, Jiangsu, China)

机构地区：[1]上海市宝山区罗店医院妇产科,上海201908 [2]同济大学附属同济医院妇产科,上海200065 [3]南京医科大学附属南京医院妇科,南京210029

出　　处：《中国临床医学》2018年第6期963-966,共4页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨B7-H4和B7-H6蛋白在卵巢良性和恶性肿瘤中的表达及其临床病理意义。方法:收集同济大学附属同济医院卵巢肿瘤标本101例,其中卵巢恶性肿瘤58例、同期卵巢良性肿瘤43例。采用免疫组织化学染色检测B7-H4和B7-H6蛋白在良性及恶性卵巢肿瘤中的表达及分布。采用χ~2检验及非参数秩和检验分析卵巢恶性肿瘤中B7-H4和B7-H6蛋白表达与临床病理参数的相关性。结果:B7-H4和B7-H6蛋白在卵巢恶性肿瘤中表达率分别为82.76%(48/58)、79.31%(46/58),在卵巢良性肿瘤中的表达率分别为13.95%(6/43)、16.28%(7/43);B7-H4和B7-H6的表达在卵巢良恶性肿瘤间差异有统计学意义(P<0.000 1)。B7-H4和B7-H6蛋白在卵巢恶性肿瘤细胞浆和细胞膜上均有表达。B7-H4和B7-H6蛋白的表达与卵巢恶性肿瘤患者的年龄、组织分型及p53蛋白表达相关(P<0.05)。结论:B7-H4和B7-H6蛋白在卵巢恶性肿瘤中呈高表达,提示两者可能与卵巢恶性肿瘤的发生、发展有关。Objective:To investigate the expressions of B7-H4and B7-H6in ovarian tumor tissues and related clinicopathological characteristics.Methods:A total of101ovarian tumor specimens from Tongji Hospital Affiated to Tongji University were collected,among which43cases were benign and58cases were malignant.The expressions and distributions of B7-H4and B7-H6in ovarian benign and malignant tumors were investigated by immunohistochemical staining.Chi-square test and nonparametric rank sum test were used to analyze the correlation between B7-H4and B7-H6protein expressions and clinicopathological parameters.Results:Immunohistochemical results showed that82.76%(48/58)of malignant tumors expressed B7-H4and79.31%(46/58)of malignant tumors expressed B7-H6,respectively.While in benign ovarian tumors,there were13.95%(6/43)and16.28%(7/43)samples that expressed B7-H4and B7-H6.The expressions of B7-H4and B7-H6proteins in ovarian malignant tumors is significantly higher than that in benign ovarian tumors(P<0.05).B7-H4and B7-H6proteins were mostly distributed in the cytoplasm and cell membrane.Moreover,the expression levels of B7-H4and B7-H6proteins in ovarian cancers were tightly correlated with the patients’age,histological type of tumors,and p53expression(P<0.05).Conclusions:The high expressions of B7-H4and B7-H6proteins in ovarian malignant tumors indicates their potential roles in the occurrence and progress of ovarian malignant tumors.

关 键 词：卵巢癌 协同刺激分子 B7-H4 B7-H6 

分 类 号：R737.31[医药卫生—肿瘤]