右美托咪定对老年腹腔镜结直肠癌根治术患者炎症因子及免疫功能的影响探究  

Effect of dexmedetomidine on inflammatory factors and immune function in elderly patients undergoing laparoscopic radical resection of colorectal cancer

作　　者：高玉华[1] 刘斌[1] 任雪艳[1] 张冬梅[1] 吴芳[1] 李军[1] 

机构地区：[1]宁夏医科大学总医院,宁夏银川750004

出　　处：《结直肠肛门外科》2018年第A02期20-21,共2页Journal of Colorectal & Anal Surgery

摘　　要：目的探讨在老年腹腔镜结直肠癌根治术中应用右美托咪定对患者的炎症因子和免疫功能的影响。方法选取在医院接受腹腔镜结直肠癌根治术的90例老年患者作为此次研究对象,随机均分,两组患者进行麻醉诱导后,对照组应用生理盐水,研究组应用右美托咪定,对比两组患者的免疫功能和各项炎症因子。结果术后1天和3天,研究组各项炎症指标均明显低于对照组,第3天和术前无明显差异;术后1d的各项免疫指标均高于对照组。结论在老年腹腔镜结直肠癌根治术中应用右美托咪定,有效缓解炎症反应,提高患者的免疫能力,值得推广。Objective to explore the effect of dexmedetomidine on inflammatory factors and immune function in senile laparoscopic radical resection of colorectal cancer.Methods a total of 90 elderly patients who received laparoscopic colorectal cancer radical resection in the hospital were selected as subjects of this study.They were randomly divided into two groups.After anesthesia induction in the two groups,normal saline was applied in the control group and dexmedetomidine was applied in the study group.Results the inflammatory indexes in the study group were significantly lower than those in the control group 1 and 3 days after surgery,and there was no significant difference between 3 and 3 days before surgery.All the immune indexes were higher than that of the control group.Conclusion the application of dexmedetomidine in laparoscopic radical resection of colorectal cancer in senile patients can effectively alleviate the inflammatory reaction and improve the immune ability of the patients.

关 键 词：腹腔镜结直肠癌根治术 老年患者 右美托咪定 炎症因子 免疫功能 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]