MGMT基因多态性与前列腺癌易感性的Meta分析  

Association between polymorphisms in MGMT and prostate cancer susceptibility:A Meta-analysis

作　　者：赵克栋[1] 郭宗华[1] 孔东波[1] Zhao Kedong;Guo Zonghua;Kong Dongbo(Department of Urology,Xianning Central Hospital,the First Affiliated Hospital of Hubei University of Science and Technology,Hubei Xianning 437000,China.)

机构地区：[1]咸宁市中心医院湖北科技学院附属第一医院泌尿外科,湖北咸宁437000

出　　处：《现代肿瘤医学》2019年第1期98-103,共6页Journal of Modern Oncology

摘　　要：目的:探讨6-甲基鸟嘌呤甲基转移酶(6O-methylguanine-DNA methyltransferase,MGMT)基因多态性与前列腺癌(prostate cancer,PCa)发病易感性的关联。方法:通过检索Pub Med、CNKI和万方数据库从1970年1月1日至2016年12月31日国内外已经公开发表的中、英文献,筛选合格文献行Meta分析。结果:最终纳入关于MGMT基因多态性与PCa易感性关联的病例-对照研究11项,共计病例组5 143例,对照组8 118例。Meta分析结果显示,MGMT基因rs12917多态性位点与PCa显著相关(TT vs CC:P=0. 047,TT vs CC+CT:P=0. 038)。以种族进行亚组分析显示,MGMT基因rs12917多态性位点在亚洲人中与PCa显著相关(T vs C:P=0. 008,TC vs CC:P=0. 013,TC+TT vs CC:P=0. 009,TC vs CC+TT:P=0. 014)。然而MGMT基因的rs2308327和rs2308321多态性位点和PCa的易感性无关。结论:本Meta分析结果认为MGMT基因rs12917多态性位点与PCa的易感性相关,可作为PCa患者潜在的诊断、筛查分子标志物。Objective:To explore the relevance between MGMT polymorphisms and prostate cancer susceptibility.Methods:We retrieved PubMed,CNKI and Wanfang databases to search for all eligible studies published from Jan 1,1970 to 0ct 31,2016 to conduct a Meta-analysis.Results:A total of 11 case-control studies were enrolled,including 5 143 cases and 8 118 controls.Our work demonstrated that rs12917 polymorphisms in MGMT significantly associated with prostate cancer susceptibility(TT vs CC:P=0.047,TT vs CC+CT:P=0.038).In the stratification analysis by ethnicity,we identified an increased risk of rs12917 polymorphism and prostate cancer susceptibility in Asian population(T vs C:P=0.008,TC vs CC:P=0.013,TC+TT vs CC:P=0.009,TC vs CC+TT:P=0.014).However,no association was identified between rs2308327 and rs2308321 polymorphisms in MGMT and prostate cancer susceptibility.Conclusion:There is a positive relevance between rs12917 polymorphisms and prostate cancer susceptibility,which can serve as a diagnosis and screening molecular biomarker for prostate cancer patients.

关 键 词：前列腺癌 PCa MGMT 易感性 META分析 

分 类 号：R737.25[医药卫生—肿瘤]