SATB1在南疆维汉妇女宫颈病变组织中的表达及意义  

Expression and significance of SATB1 in Uygur and Han in southern Xinjiang in cervix lesions

作　　者：肇丽杰[1] 郑玉华[1] 张晓泉 谭子贵 张小英 Zhao Lijie;Zheng Yuhua;Zhang Xiaoquan;Tan Zigui;Zhang Xiaoying(Maternal and Child Health Hospital of Foshan,Guangdong Foshan 528000,China;Jiashi County People's Hospital of Kashi Region,Xinjiang Kashi 844000,China.)

机构地区：[1]佛山市妇幼保健院,广东佛山528000 [2]新疆喀什地区伽师县人民医院,新疆喀什844000

出　　处：《现代肿瘤医学》2019年第1期131-133,共3页Journal of Modern Oncology

基　　金：广东省科技厅课题(编号:2015A020210002)

摘　　要：目的:探讨南疆维吾尔族与汉族妇女宫颈病变组织中SATB1的表达及其意义。方法:采用免疫组化法检测300例(150例维吾尔族、150例汉族)妇女宫颈癌组织、宫颈上皮内瘤样病变组织(cervical intraepithelial neoplasias,CIN)、慢性宫颈炎组织中特异AT序列结合蛋白1 (special AT-rich sequence binding protein,SATB1)的表达。结果:不同程度宫颈病变组之间SATB1的表达差异有统计学意义(P=0. 00),CINⅠ组与慢性宫颈炎组表达差异无统计学意义(P=0. 38)。SATB1在维汉族妇女宫颈病变组织中的表达差异无统计学意义(P=0. 69)。结论:SATB1的表达不存在维汉民族差异性,表明在南疆维吾尔族和汉族宫颈癌的发生、发展中SATB1的表达具有共同性,无民族间基因背景差异。SATB1在宫颈癌组织中的表达高于宫颈上皮内瘤样病变组织、慢性宫颈炎组织,提示SATB1的表达与宫颈病变及其癌变的发生发展关系密切,如进一步研究可能对宫颈癌的治疗提供理论依据。Objective:To evaluate the expression and clinical signifcance of SATB1 in Uygur and Han in southern Xinjiang in cervix cancer.Methods:The expressions of special AT-rich sequence binding protein(SATB1)in 300 patients with cervix cancer,cervical intraepithelial neoplasias(CIN),cervicitis(Uygur 150 cases,Han 150 cases)were investigated with immunohistochem technique.Results:The expression of SATB1 had a significant difference between different degree of cervical lesions groups(P=0.00),except the contrast of CINⅠgroup and cervicitis group(P=0.38).There was no significant difference in the expression of SATB1 between Uygur and Han women(P=0.69).Conclusion:The expression of SATB1 had no significance difference among different nationalities.Show that SATB1 expression of commonality in Han and Uygnr in southern Xinjiang at the occurrence and development of cervix cancer has no inter-ethnic differences in genetic background.The expression of SATB1 in patients with cervix cancer are higher than in CIN and normal cervix organize,if further studying may offer the theoretical foundation to the treatment of cancer of the cervix.

关 键 词：宫颈癌 SATB1 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]