非小细胞肺癌组织中PD-L1蛋白表达与^(18)F FDG-PET/CT显像特征的关系  

Relationship between the expression of PD-L1 protein and the features of ^(18)F and FDG-PET/CT in non small cell lung cancer

作　　者：付立武 FU Li-wu(Department of Nuclear Medicine, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan 471000, China)

机构地区：[1]郑州大学附属洛阳中心医院核医学科,河南洛阳471000

出　　处：《临床肺科杂志》2019年第1期107-110,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究非小细胞肺癌组织中程序性细胞死亡配体1(PD-L1)蛋白的表达和^(18)F-脱氧葡萄糖(FDG) PET/CT显像特征的关系。方法选择2016年3月-2017年3月我院收治的非小细胞肺癌患者60例为研究对象,先对患者行^(18)F FDG-PET/CT检查,并在其行肿瘤切除术后进行组织病理检查,观察PD-L1在病理组织中的表达。结果高分化组、中分化组、低分化组最大标准化摄取值(SUVmax)、平均标准化摄取值(SUVavg)、PD-L1阳性细胞百分比比较,差异有统计学意义(P <0. 05),其中,低分化组、中分化组SUVmax值、SUVavg均高于高分化组(P <0. 05),低分化组病灶内PD-L1阳性细胞百分比高于高分化组(P <0. 05))。非小细胞肺癌病灶SUVmax值与PD-L1指数在相关性散点图上存在明显直线相关关系,Spearman分析显示病灶SUVmax值与PD-L1指数呈正相关(r=0. 705,P <0. 001)。结论非小细胞肺癌组织SUV max值和组织PD-L1表达呈正相关性,病灶SUV max在一定程度上可以反映肿瘤组织PD-L1水平,可为此类患者的诊治提供有价值的参考。Objective To investigate the relationship between the expression of programmed cell death ligand 1(PD-L1)and the characteristics of 18 F-fluorodeoxyglucose(FDG)PET/CT imaging in non small cell lung cancer.Methods 60 NSCLC patients from March 2016 to 2017 were given 18 F FDG-PET/CT examination,and the resection was performed after histopathological examination,to observe the expression of PD-L1 in pathological tissues.Results There were significant differences in SUVmax,SUVavg,and PD-L1 positive cells percentage among the high differentiation group,the middle differentiation group,and the low differentiation group(P<0.05).The value of SUVmax and SUVavg was higher in the low differentiation group and the middle differentiation group than in the differentiation group(P<0.05),and the percentage of PD-L1 positive cells was higher in the low differentiation group than in the high differentiated group(P<0.05).The correlation between the SUVmax value and PD-L1 in non small cell lung cancer showed a linear correlation in the scatter plot.Spearman analysis showed that the SUVmax value of the lesions was positively correlated with the PD-L1 index(r=0.705,P<0.001).Conclusion In patients with non small cell lung cancer,the expression of PD-L1 and SUVmax are positively correlated in lung cancer tissues,which means SUVmax can reflect the level of PD-L1 in tumor tissue and can provide valuable reference for the diagnosis and treatment of such patients.

关 键 词：非小细胞肺癌 程序性细胞死亡配体1 18氟-脱氧葡萄糖 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤]