循环肿瘤细胞检测技术及其在肿瘤侵袭转移中的研究进展  

Research Progress in the Detection Technology of Circulating Tumor Cells and Its Application in Tumor Invasion and Metastasis

作　　者：孙建兵 汪亚辉 马凯 于建平[1] 李洪涛[1] 韩晓鹏[1] 刘宏斌[1] 曹廷宝[1] 魏登文[1] SUN Jianbing;WANG Yahui;MA Kai;YU Jianping;LI Hongtao;HAN Xiaopeng;LIU Hongbin;CAO Tingbao;WEI Dengwen(Department of General Surgery,Lanzhou General Hospital of Lanzhou Military Area,Lanzhou 730050,China)

机构地区：[1]兰州军区兰州总医院普通外科,兰州730050

出　　处：《医学综述》2018年第23期4652-4657,共6页Medical Recapitulate

基　　金：甘肃省自然科学基金(1506RJZA309)

摘　　要：恶性肿瘤的防治是一项世界性难题,其复发、侵袭及转移是预后较差的一个重要因素。被称为肿瘤液相活检技术的循环肿瘤细胞(CTCs)检测技术运用于肿瘤的早期诊断、预后评价、疗效评估、复发风险评估及个体化治疗等方面。肿瘤的侵袭转移是在肿瘤微环境中由多种分子参与、通过多种信号通路、涉及肿瘤细胞从原发灶或转移灶脱落、上皮-间充质转化、细胞外基质降解、浸润穿透基膜和远处转移等多步骤、多环节的复杂过程。基于CTCs的不同特性,其检测方法亦不同。随着检测技术的不断成熟和学者对CTCs的进一步认识,其临床应用价值日趋明显。未来,深入探讨CTCs与肿瘤进展之间的关系,有望为抑制肿瘤的发生发展提供新思路。The prevention and treatment of malignant tumor is a worldwide problem.The recurrence,invasion and metastasis of malignant tumor are important factors of poor prognosis.Circulating tumor cells(CTCs),known as tumor fluid biopsy,have been used in early diagnosis,prognosis evaluation,efficacy monitoring,recurrence risk assessment and individualized therapy.Invasion and metastasis of tumor is a multi-tep,multi-link and complex process involving many molecules and signaling pathways in the tumor microenvironment.And it involves the exfoliation of tumor cells from metastatic lesion or a solid tumor,epithelial-mesenchymal transition,degradation of extracellular matrix,infiltration through the basement membrane and distant metastasis.Based on the different characteristics of CTCs,the test methods are also different.With the continuous maturing of the detection technology and the further understanding of CTCs by scholars,its clinical application value is becoming more and more obvious.In the future,further study of the relationship between CTCs and tumor progre-ssion is expected to provide new ideas to inhibit the occurrence and development of tumor.

关 键 词：肿瘤 循环肿瘤细胞 侵袭转移 

分 类 号：R733[医药卫生—肿瘤]