胎儿超声软指标异常与不良妊娠结局的临床价值研究  

The clinical significance of abnormal genetic ultrasound soft markers in pregnancy outcomes

作　　者：陶华娟 王春霞[1] 李晓东[1] 张胜利[1] 蔡绪英[1] TAO Hua-juan;WANG Chun-xia;LI Xiao-dong

机构地区：[1]潍坊市妇幼保健院,山东潍坊261011

出　　处：《中国产前诊断杂志（电子版）》2018年第3期18-20,共3页Chinese Journal of Prenatal Diagnosis(Electronic Version)

摘　　要：目的探讨孕期遗传学超声软指标异常与不良妊娠结局的相关关系。方法收集6 729例孕11～13+6周行NT(NT增厚时在11～20周加做三尖瓣血流、静脉导管a波)、鼻骨超声检查的胎儿,对胎儿进行评估及妊娠结局随访,并对结果进行统计学分析。结果 6 729例胎儿中出现NT异常及鼻骨发育异常共283例(4.2%),随访不良妊娠结局胎儿共86例,不良妊娠结局发生率为30.4%;NT厚度与胎儿不良妊娠结局发生情况呈正相关(R=0.97,P<0.05);283例中合并三尖瓣反流或静脉导管a波异常共74例,不良妊娠结局胎儿33例,不良妊娠结局发生率为44.6%。结论 NT增厚及鼻骨发育异常对胎儿不良妊娠结局具有一定的预测价值,如合并三尖瓣反流或静脉导管异常胎儿发生不良结局的风险更高。Objective To inspect the clinical significance of abnormal genetic ultrasound soft markers in pregnancy outcomes.Method Collecting ultrasound examination results about NT(tricuspid valve flow,a wave in ductus venous)or NF,fetal nasal bone of6729fetus in Weifang Maternal And Child Health Hospital during August2013to November2016.To evaluate and counsel fetal abnormalities,prenatal screening,prenatal diagnosis,and intensive follow-up are necessary.The normal fetus was performed during pregnancy and postnatal follow-up.The results were analyzed statistically.Results There were283fetuses who were found NT thickened or abnormal nasal bone development in6729fetuses(4.2%),and86fetuses suffered from bad pregnancy outcomes(30.4%).Between NT thickened and pregnancy outcomes have positive correlation(R=0.97,P<0.05).Only NT thickened152cases were found that the positive fetus were39cases(25.7%);The tricuspid regurgitation or lack of the a wave in ductus venous fetuses in NT thickened were74cases(44.6%).Conclusions NT and nasal bone have predictive value to pregnancy outcomes,and the prediction will have more value with tricuspid regurgitation or lack of the a wave in ductus venous.

关 键 词：NT 胎儿鼻骨 胎儿三尖瓣血流 胎儿静脉导管a波 不良妊娠结局 

分 类 号：R445.1[医药卫生—影像医学与核医学]