阿加曲班序贯疗法结合红花黄色素治疗老年多发性腔隙性脑梗死的效果  

The effect of Argatroban sequential therapy combined with Safflower Yellow Pigment in the treatment of multiple lacunar cerebral infarction in the elderly

作　　者：王洪娇 周洁信[1] 母玉元 刘洋[1] 谭辰熙 孟鑫 WANG Hongjiao;ZHOU Jiexin;MU Yuyuan;LIU Yang;TAN Chenxi;MENG Xin(The First Department of the Neurology, the Second Affiliated Hospital of Qiqihar Medical University, Heilongjiang Province, Qiqihar 161000, China;Magmatic Resonance Imaging Room, the Third Affiliated Hospital of Qiqihar Medical University, Heilongjiang Province, Qiqihar 161000, China)

机构地区：[1]齐齐哈尔医学院附属第二医院神经内一科,黑龙江齐齐哈尔161000 [2]齐齐哈尔医学院附属第三医院磁共振室,黑龙江齐齐哈尔161000

出　　处：《中国医药导报》2018年第35期74-77,81,共5页China Medical Herald

基　　金：黑龙江省教育厅基本科研业务费项目(2016-KYYWF-0875)

摘　　要：目的探讨阿加曲班序贯疗法结合红花黄色素治疗老年多发性腔隙性脑梗死的效果。方法选取2015年12月～2016年12月齐齐哈尔医学院附属第二医院神经内科病房收治的118例老年多发性腔隙性脑梗死患者为研究对象。采用随机数字表法将其分为观察组与对照组,每组各59例。对照组在常规用药基础上进行阿加曲班序贯治疗,观察组在对照组治疗基础上联合红花黄色素治疗,比较两组患者治疗效果及神经功能、脑血流速度恢复情况及对肝肾功能、凝血指标的影响。结果治疗2个月后两组患者治疗效果比较,差异有统计学意义(P <0.05),两组治疗后神经功能缺损量表(NIHSS)评分、残障程度改良量表(MRS)评分均低于治疗前,差异有统计学意义(P <0.05),且治疗后观察组NIHSS评分、MRS评分均低于对照组,差异有统计学意义(P <0.05);两组颅内段血管基底动脉(BA)、大脑中动脉(MCA)、大脑前动脉(ACA)收缩期最大血流流速均高于治疗前,差异有统计学意义(P <0.05),且治疗后观察组BA、MCA、ACA明显高于对照组,差异有统计学意义(P <0.05);两组患者治疗前后肝肾功能及凝血指标比较,差异无统计学意义(P> 0.05),治疗期间均未发生严重药物不良反应。结论采用阿加曲班序贯疗法结合红花黄色素可有效治疗老年多发性腔隙性脑梗死,改善患者神经功能缺损及残障状态,促进脑组织血液供应。Objective To discuss the effect in the treatment of senile multiple lacunar infarction with Argatroban sequential therapy and Safflower Yellow Pigment.Methods One hundred and eighteen elderly patients with multiple lacunar cerebral infarction admitted to the Department of Neurology,the Second Affiliated Hospital of Qiqihar Medical University from December2015to December2016were selected as the study objects.The random number table method was used to divide the patients into observation group and the control group,with59cases in each group.The control group was treated with Argatroban sequential therapy on the basis of conventional drugs,while the observation group was treated with Safflower Yellow Pigment on the basis of the treatment regimen of the control group,and the therapeutic effect,neurological function,cerebral blood flow velocity and the effect on liver and kidney function and coagulation indexes were compared between the two groups.Results After2months of treatment,the therapeutic effect of the two groups was compared,and the difference was statistically significant(P<0.05).The scores of national institule of health seroke scale(NIHSS)and medified rankin scale(MRS)of the two groups after treatment were lower than those before treatment,the differences were statistically significant(P<0.05).The NIHSS and MRS scores of the observation group were lower than those of the control group after treatment,the differences were statistically significant(P<0.05).After treatment,the maximal blood flow velocity in the systolic period of basilar artery(BA),middle cerebral artery(MCA)and anterior cerebral artery(ACA)of in tracranial vessels in the two groups were higher than those before treatment,the differences were statistically significant(P<0.05).After treatment,the rates of BA,MCA and ACA in the observation group were significantly higher than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in liver and kidney function and coagulatio

关 键 词：阿加曲班序贯疗法 红花黄色素 多发性腔隙性脑梗死 神经功能缺损 

分 类 号：R741.5[医药卫生—神经病学与精神病学]