黑素皮质素受体-4基因rs489693位点多态性与慢性精神分裂症患者体质量指数及糖脂代谢水平的关系  

Association between the polymorphism of melanocortin 4 receptor gene rs489693 and body mass index,glucolipid metabolism in patients with chronic schizophrenia

作　　者：徐静文[1] 刘群[1] 管晓波[1] 应启昂 童艳晨 陆峥[2] 刘飞[2] 龙翔云[2] XU Jing-wen;LIU Qun;GUAN Xiao-bo;YING Qi-ang;TONG Yan-chen;LU Zheng;LIU Fei;LONG Xiang-yun(The Third Civil Mental Center of Shanghai,Shanghai200435,China)

机构地区：[1]上海市民政第三精神卫生中心,200435 [2]同济大学附属同济医院

出　　处：《临床精神医学杂志》2018年第6期382-386,共5页Journal of Clinical Psychiatry

基　　金：上海市重中之重临床重点学科(2017ZZ02020)

摘　　要：目的:探讨慢性精神分裂症患者黑素皮质素受体-4基因(MC4R) rs489693多态性与患者体质量指数(BMI)、糖脂代谢的相关性。方法:135例慢性精神分裂症患者根据DNA测序法检测MC4R基因rs489693位点的多态性分为CC组67例、AC组50例、AA组18例,并测定3组患者体质量、腰围、BMI,血清总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、血糖、糖化血红蛋白、尿酸及催乳素水平,使用方差分析比较各组间各变量的差异。结果:rs489693基因分布频率均符合Hardy-Weinberg平衡检验(χ2=2. 91,P=0. 09)。CC组、AC组及AA组在体质量(F=4. 041,P=0. 025)、BMI(F=3. 337,P=0. 045)、血清总胆固醇(F=3. 184,P=0. 036) 3项变量差异有统计学意义;事后多重比较发现AA组体质量、BMI、血清总胆固醇3项变量显著高于CC组(P均<0. 05); Logistic回归分析发现BMI与基因型AA有关(OR=22. 071,95%CI:1. 803～270. 22; P=0. 015)。结论:MC4R基因rs489693的A等位基因是慢性精神分裂症患者发生肥胖和高血脂的风险因素。Objective:To investigate the association between the polymorphism of melanocortin4receptor gene(MC4R)rs489693and body mass index(BMI),glucose and lipid metabolism,prolactin in patients with chronic schizophrenia.Method:One hundred and thirty-five patients with chronic schizophrenia were recruited.Gene(MC4R)rs489693polymorphisms were detected by DNA sequencing technology and genotype AA(n=18),AC(n=50)and CC(n=67)were determined in135patients.Their weight,waist,BMI,cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,trioxypurine,prolactin were measured.An analysis of covariance was used to compare the differences between the three groups.Results:The distribution of rs489693polymorphism had goodness fit of Hardy-Weinberg equilibrium for the whole subjests(χ2=2.91,P=0.09).There were significance differences in weight(F=4.041),BMI(F=3.337)amd cholesterol(F=3.184)between the three groups(all P<0.05).The Post Hoc comparisons by LSD method showed that AA-genotype patients had higher weight,BMI and cholesterol than CC-genotype patients(all P<0.05).Logistic regression analysis showed that AA was associated with BMI(OR=22.071,95%CI:1.803-270.22;P=0.015)and genotype.Conclusion:Our results suggest rs489693A-allele is a possible risk factor for obesity and hyperlipidemia in patients with chronic schizophrenia.

关 键 词：慢性精神分裂症 体质量 糖脂代谢 黑皮素受体-4基因 

分 类 号：R749.3[医药卫生—神经病学与精神病学]