认知功能损害老人血清细胞因子水平的对照研究  

The serum cytokine levels in old people with cognitive impairments: a controlled study

作　　者：邵园 吴东辉[1] 王建[1] 冯飞[1] 宋伟东 陈宇[2] 邹良玉[3] SHAO Yuan;WU Dong-hui;WANG Jian;FENG Fei;SONG Wei-dong;CHEN Yu;ZOU Liang-yu(Department of Geriatric Psychiatry,Shenzhen Mental Health Center,Shenzhen518000,China)

机构地区：[1]深圳市康宁医院老年精神科,518000 [2]香港科技大学 [3]暨南大学第二临床学院深圳市人民医院神经内科

出　　处：《临床精神医学杂志》2018年第6期403-405,共3页Journal of Clinical Psychiatry

基　　金：深圳市医疗卫生三名工程(SZSM201412023);深圳市科技计划项目(JCYJ20160422170522075)

摘　　要：目的:探讨认知功能损害的老人血清炎症因子白介素-1β(IL-1β)、IL-4、IL-6及干扰素-γ(IFN-γ)水平变化的特点。方法:78名≥60岁老人根据蒙特利尔认知评估量表(MoCA)总分分为认知损害组(54人)和认知正常组(对照组24人);使用人定量酶联免疫吸附测定两组血清IL-1β、IFN-γ、IL-4、IL-6的浓度,并进行比较。结果:认知损害组血清IL-1β(t=-4. 95,P=0. 000)、IFN-γ(t=-2. 44,P=0. 018)、IL-6(t=-2. 76,P=0. 007)浓度均高于对照组; IL4/IL1β比值(t=3. 99,P=0. 000)及IL4/IFN-γ比值(t=3. 10,P=0. 004)低于对照组; IL-4(t=-1. 04,P=0. 304)及IL4/IL6比值(t=-0. 77,P=0. 442)两组间比较,差异无统计学意义。结论:血清IL-1β、IFN-γ和IL-6浓度增高可能是老人认知功能受损的生物学标记物。Objective:To explore serum interleukin featuress of the cytokines(IL-1β,IL-4,IL-6)and interferon(IFN-γ)in the aged people with cognitive impairments.Method:A total of78old people(≥60years)were divided into cognitive impairment group(n=54)and normal control group(n=24)in terms of Montreal cognitive assessment(MoCA)score.Serum levels of IL-1β,IL-4,IL-6and IFN-γwere measured using enzyme-linked immunosorbent assay(ELISA)kits.Results:Serum levels of IL-1β(t=-4.95,P=0.000),IFN-γ(t=-2.44,P=0.018)and IL-6(t=-2.76,P=0.007)in the cognitive impairment group were significantly higher than those in the normal control group.The ratios of IL4/IL1β(t=3.99,P=0.000)and IL4/IFN-γ(t=3.10,P=0.004)were significantly lower in the cognitive impairment group compared with normal control group.Serum levels of IL-4(t=-1.04,P=0.304)and IL4/IL6(t=-0.77,P=0.442)were not significantly different in the two groups.Conclusion:The study result suggests IL-1β,IFN-γand IL-6could be used as one of biomarkers in the diagnosis of senior cognitive impairment.

关 键 词：认知功能损害 血清细胞因子 老人 

分 类 号：R749[医药卫生—神经病学与精神病学]