肾间质纤维化动物模型在基因调控实验教学中的应用  

Application of animal models of renal interstitial fibrosis in experimental teaching of gene regulation

作　　者：肖菲[1] 戴欢子[1] XIAO Fei;DAI Huanzi(Department of Nephrology, Institute of Field Surgery, Daping Hospital, Army Military Medical University, Chongqing 400042, China)

机构地区：[1]陆军军医大学大坪医院野战外科研究所肾内科,重庆400042

出　　处：《中国医药导报》2018年第34期61-64,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(81300593)

摘　　要：目的探讨肾间质纤维化动物模到在基因调控实验教学中的应用。方法选取2016年9月～2017年9月陆军军医大学2014级及2013级医学生物技术专业60名本科生作为研究对象,按照简单随机法分为两组,每组30名学生。对照组采用常规方法进行基因调控实验教学,观察组采用肾间质纤维化动物模型进行基因调控实验教学。比较两组老师及学生评教情况、学生结课考试成绩及学生对教学效果的评价。结果观察组教师及学生对教学过程、教学引导、教学效果评分高于对照组,差异均有统计学意义(P <0.05或P <0.01)。观察组学生教学后理论考试、实践技能考试成绩均高于对照组,差异均有高度统计学意义(P <0.01)。观察组对于教学方法总体印象好、培养实验动手能力、学生通过实验课能够很好地掌握理论知识、实验能培养学生的创新思维、培养学生团队协作能力、所接受教学方式满意的学生占比均高于对照组,差异均有高度统计学意义(P <0.01)。结论肾间质纤维化动物模型应用于基因调控实验教学中,能够提高学生的学习兴趣及学习成绩,并提高教学质量。Objective To explore the application of animal models of renal interstitial fibrosis in experimental teaching of gene regulation.Methods From September2016to September2017,60undergraduate students from 2012 and 2013 medical biotechnology majors in Army Military Medical University were selected as the research subjects.The students were randomly divided into two groups,30students in each group.The conventional method was used in the control group for gene regulation experiment teaching,while the renal interstitial fibrosis animal model to carry out gene control experiment teaching was used in observation group.Then rated the teaching situation of teachers and students in two groups,students′final exam results and students′evaluation of teaching effect.Results The scores of teaching process,teaching guidance and teaching effect of teachers and students in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05or P<0.01).The scores of theoretical examination and practical skill examination in the observation group were higher than those in the control group,the differences were highly statistically significant(P<0.01).The students′overall impression of teaching methods,cultivation of experimental practical ability,students′good grasp of theoretical knowledge through experimental courses,experimental ability to cultivate students′innovative thinking,cultivate students′team cooperation ability,and the satisfaction rate of accepted teaching methods in the observation group were higher than those in the control group,the differences were highly statistically significant(P<0.01).Conclusion The application of animal models of renal interstitial fibrosis in experimental teaching of gene regulation can improve students′interest in learning and academic performance,and improve teaching quality.

关 键 词：肾间质纤维化动物模型 基因调控 实验教学 

分 类 号：R692[医药卫生—泌尿科学]