CT肝灌注成像技术在肝纤维化诊断中的临床应用价值探讨  

The Clinical Application Value of CT Liver Perfusion Imaging in the Diagnosis of Liver Fibrosis

作　　者：朱小成 Zhu Xiaocheng(Department of Radiology,Chancheng High - tech Zone Hospital,Foshan Traditional Chinese Medicine Hospital,Guangdong Province,528300)

机构地区：[1]广东省佛山市中医院禅城高新区医院放射科,528300

出　　处：《现代医用影像学》2018年第5期1458-1460,共3页Modern Medical Imageology

摘　　要：目的:分析CT肝灌注成像技术在肝纤维化诊断中的应用价值。方法:选取2016年1月-2017年12月50例慢性肝炎引起的肝纤维化患者作为观察组,所有患者均行穿刺活检确诊;并选取同时段50例健康体检者作为对照组,所有体检者结合临床病史、体格、影像学和实验室检查证实没有肝肾疾病。两组均行螺旋CT灌注扫描,并比较两组在肝动脉灌注量(ALP)、门静脉灌注量(PVP)、肝脏灌注指数(HPI)、血流量(BF)、血容量(BV)以及渗透性(P)。结果:观察组与对照组相比,ALP与P的比较差异无统计学意义,但在PVP、HPI、BF、BV方面的比较差异有统计学意义(P <0. 05);在观察组内,不同程度的肝纤维化患者,在HPI、PVP、BF以及BV等方面的差异有统计学意义,但在ALP和P方面的差异无统计学意义,并且随着肝纤维化程度的加重,PVP、BF、BV呈逐渐下降的趋势,而HPI则呈逐渐升高的趋势。结论:CT肝灌注成像技术能够反映肝脏的血流动力学指标,而肝纤维化患者的肝脏血流灌注指标与健康人群之间有着较大的差异,并且与疾病严重程度有密切的相关性,在临床诊断中具有较好的应用价值。Objective: to analyze the value of CT liver perfusion imaging in the diagnosis of liver fibrosis. Methods: the patients with hepatic fibrosis caused by chronic hepatitis from January 2016 to December 2017 were selected as the observation group. All patients were diagnosed with puncture biopsy. In addition,50 healthy patients were selected as the control group,and all the patients were confirmed without liver and kidney diseases combined with clinical history,physique,imaging and laboratory examination. Two groups were performed spiral CT perfusion scanning,and compare the two groups in the hepatic artery perfusion(ALP) and portal venous perfusion(PVP),hepatic perfusion index(HPI),blood flow(BF),blood volume(BV) and permeability(P). Results: compared with the control group,the comparison between ALP and P was not statistically significant,but the differences in PVP,HPI,BF and BV were statistically significant(P <0. 05). In the observation group,patients with different degree of liver fibrosis,in such aspects as the HPI,PVP,BF and BV difference was statistically significant,but no statistically significant difference in ALP and P,and as the degree of liver fibrosis is aggravating,PVP,BF,BV showed a trend of gradual decline,whereas the HPI was gradually rising trend. Conclusion: CT perfusion imaging technique can reflect the liver liver hemodynamics indexes,and liver fibrosis in patients with hepatic perfusion index and has a larger difference between healthy people,and there is a close correlation with the severity of disease,has good application value in clinical diagnosis.

关 键 词：CT肝灌注成像技术 肝纤维化 应用价值 

分 类 号：R575.2[医药卫生—消化系统]