阿托品对单色光中豚鼠屈光发育的干预作用  

Intervention effect of atropine on refractive development of guinea pigs in different monochromatic lights

作　　者：钱一峰 肖艳辉[1] 陈志刚[1] 陆培荣[1] QIAN Yifeng;XIAO Yanhui;CHEN Zhigang;LU Peirong(Department of Ophthalmology,First Affiliated Hospital of Soochow University,Suzhou Jiangsu 215006,China)

机构地区：[1]苏州大学附属第一医院眼科,江苏苏州215006

出　　处：《眼科学报》2018年第4期260-266,共7页Eye Science

基　　金：国家自然科学基金(81400429);江苏省自然科学青年基金项目(BK20140290);江苏省"科教强卫"青年医学人才项目(QNRC2016717)~~

摘　　要：目的:研究阿托品作用下豚鼠眼在不同单色光中的屈光发育情况。方法:24只2周龄3色种豚鼠被随机分成3组,分别在蓝光(430 nm)、绿光(530 nm)和白光(色温5000k)中饲养。3组豚鼠的双眼从实验开始点1%阿托品滴眼液,1次/d,持续6周。实验前后测量豚鼠屈光度和眼球生物参数。结果:实验开始时3组各测量结果差异均无统计学意义。实验起始时各组平均屈光度约为4.3 D。实验结束时白光组平均屈光度约为4.84D,绿光组约为3.47D,蓝光组约为6.19 D,3组间屈光度差异显著,且3组前后屈光度变化量比较差异显著。各组玻璃体腔长度在实验开始约为3.3 mm,实验结束时白光组约为3.25 mm,绿光组约为3.39 mm,蓝光组约为3.17 mm。此时白光组与绿光组玻璃体腔长度相比差异显著,绿光组与蓝光组相比差异显著,而白光组与蓝光组相比差异无统计学意义。实验结束时3组角膜曲率半径、前房深度和晶状体厚度无统计学差异。结论:阿托品通过干预豚鼠玻璃体腔长度的变化而影响单色光对屈光发育的作用,但单色光引起的屈光变化方向不受影响。Objective:To investigate the effect of atropine on ocular refractive development of guinea pigs in different monochromatic lights.Methods:Twenty-four guinea pigs aged 2 weeks were randomly divided into three groups,which were raised in blue light(BL,430 nm),green light(GL,530 nm)and white light(WL,color temperature 5000k),respectively.The two eyes of the guinea pigs in the three groups were treated with 1%atropine eye drops once a day for 6 weeks from the beginning of the experiment.The refraction and ocular biological parameters of the guinea pigs were measured before and after the experiment.Results:At the beginning of the experiment,there was no significant difference in every measurement among the three groups.The average refraction of each group was about 4.3 D at the beginning.At the end of the experiment,the average refraction was approximately 4.84 D in the WL,3.47 D in the GL,and 6.19 D in the BL.The differences in refraction of the three groups were significant,and the refractive changes of the three groups before and after the experiment were significant.The length of vitreous chamber in each group was approximately 3.3 mm at the beginning,but it was approximately 3.25 mm in the WL,3.39 mm in the GL and 3.17 mm in the BL at the end of the experiment.At this time,there was significant vitreous difference between the WL and the GL,and between the GL and the BL,but there was no significant difference between the WL and the BL in vitreous length.After the experiment,there was no significant difference in the radius of corneal curvature,depth of anterior chamber and lens thickness among the three groups.Conclusion:The effect of monochromatic light on refractive development is affected by atropine through intervening the vitreous length in guinea pigs,but the direction of refractive change induced by monochromatic light is not influenced.

关 键 词：正视化 屈光不正 调节反应 阿托品 单色光 豚鼠 

分 类 号：R778[医药卫生—眼科]