超声消融治疗子宫肌瘤有效性及安全性分析  

Effectiveness and Safety of Ultrasound Ablation for Uterine Leiomyoma

作　　者：吴飞华[1] 胡小荣[1] 周士源[1] Wu Feihua;Hu Xiaorong;Zhou Shiyuan(Department of TCM Gynecology,Jiangxi Hospital of Traditional Chinese Medicine,Nanchang,Jiangxi,330006,China)

机构地区：[1]江西省中医院中医妇科,江西南昌330006

出　　处：《当代医学》2018年第36期68-71,共4页Contemporary Medicine

摘　　要：目的探讨超声消融治疗子宫肌瘤有效性及安全性。方法选取本院收治的子宫肌瘤患者112例,随机分为研究组和对照组,每组56例。研究组给予超声消融治疗,对照组给予腹腔镜下子宫肌瘤剔除术治疗。比较两组患者的手术情况、并发症发生率及手术前、后卵巢功能和氧化损伤指标。结果两组患者手术时间比较差异无统计学意义。研究组术中出血量、排气时间、住院时间明显低于对照组(P<0.05)。研究组并发症发生率明显低于对照组,差异具有统计学意义(P<0.05)。两组患者术前黄体生成素(LH)、促卵泡生成素(FSH)、窦状细胞(AFC)比较差异无统计学意义;相较于术前,研究组术后1、3、6个月LH和FSH上升、AFC下降,但差异无统计学意义;对照组术后1、3、6个月LH、FSH明显上升、AFC明显下降(P<0.05);研究组术后1、3、6个月LH和FSH明显低于对照组、AFC明显高于对照组(P<0.05)。两组患者术前八廓环磷酰胺(TAC)、肌红蛋白(MYo)、缺血修饰清蛋白(IMA)比较差异无统计学意义;相较于术前,两组患者术后1、3、6个月TAC明显下降、MYo和IMA明显上升(P<0.05),但研究组改变程度明显高于对照组(P<0.05)。结论超声消融治疗子宫肌瘤临床疗效显著,并发症发生少,安全性高,可有效减轻对患者卵巢功能及氧化损伤指标的影响,值得临床推广应用。Objective To investigate the efficacy and safety of ultrasound ablation in the treatment of uterine leiomyoma.Methods112patients with uterine leiomyoma were randomly divided into study group and control group,56cases in each group.The study group was treated with ultrasound ablation,while the control group was treated with laparoscopic myomectomy.The operation conditions,complications and the indexes of ovarian function and oxidative damage before and after operation were compared between the two groups.Results There was no significant difference in operation time between the two groups.The bleeding volume,exhaust time and hospitalization time in the study group were significantly lower than those in the control group(P<0.05).The incidence of complications in the study group was significantly lower than that in the control group(P<0.05).There was no significant difference in luteinizing hormone(LH),follicle stimulating hormone(FSH)and sinusoidal cell(AFC)between the two groups before operation;LH and FSH increased and AFC decreased in the study group1,3,6months after operation,but there was no significant difference between the two groups;LH,FSH increased and AFC decreased significantly in the control group1,3,6months after operation(P<0.05);Monthly LH and FSH were significantly lower than those in the control group and AFC was significantly higher than those in the control group(P<0.05).There was no significant difference in the levels of TAC,MYo and IMA between the two groups before operation.Compared with before operation,TAC decreased significantly and MYo and IMA increased significantly in the two groups at1,3and6months after operation(P<0.05),but the degree of change in the study group was significantly higher than that in the control group(P<0.05).Conclusion Ultrasound ablation for uterine leiomyoma has significant clinical efficacy,fewer complications and high safety.It can effectively reduce the impact on ovarian function and oxidative damage index,and is worthy of clinical application.

关 键 词：超声消融 子宫肌瘤 有效性 安全性 

分 类 号：R737.33[医药卫生—肿瘤]