弥漫大B细胞淋巴瘤中Ki67表达与^(18)F-FDG PET/CT SUVmax的相关性及二者在疗效评估中的应用  

Correlation Between Ki67 Expression and ^(18)F-FDG PET/CT SUVmax in Patient with Diffuse Large B-cell Lymphoma and Their Application in Therapeutic Effect Evaluation

作　　者：杨明[1] 冯彦林[1] 刘德军[1] 余丰文[1] 黄克敏[1] 李雯[1] 冼伟均[1] 鲁胜男[1] 王颖[1] YANG Ming;FENG Yanlin;LIU Dejun;YU Fengwen;HUANG Kemin;LI Wen;XIAN Weijun;LU Shengnan;WANG Ying(Nuclear Medicine Department,The First People's Hospital of Foshan,Foshan 528000,China)

机构地区：[1]佛山市第一人民医院核医学科,佛山528000

出　　处：《肿瘤防治研究》2018年第12期1004-1008,共5页Cancer Research on Prevention and Treatment

基　　金：佛山市医学类科技攻关项目(2015AB00325)

摘　　要：目的探讨弥漫大B细胞淋巴瘤(DLBLC)中Ki67表达与18F-FDGPET/CTSUVmax的相关性及Ki67和SUVmax在疗效评估中的应用价值。方法回顾性分析55例初诊DLBLC患者的18F-FDG PET/CT表现,观察Ki67表达程度和病灶SUVmax之间相关性;应用18F-FDGPET/CT评估疗效,分析年龄、性别、病灶SUVmax、Ki67表达程度是否为影响化疗疗效的独立因素。结果 Ki67表达程度和病灶SUVmax呈正相关(P<0.05);而DCBCL病灶SUVmax与化疗疗效无明显相关性(P>0.05);年龄、性别、病灶SUVmax和Ki67表达程度都不能作为影响化疗疗效的独立影响因素(P>0.05)。结论18F-FDGPET/CTSUVmax可以预测DLBCL的增殖情况和侵袭性,与化疗疗效无相关性;年龄、性别、病灶SUVmax和Ki67表达,均不是影响化疗疗效的独立因素。Objective To discuss the correlation between Ki67 expression and 18F-FDG PET/CT SUVmax in patients with diffuse large B-cell lymphoma(DLBLC)and their application in the evaluation of chemotherapy effect.Methods We retrospectively analyzed 18F-FDG PET/CT images of 55 patients initially diagnosed as DLBLC in our hospital,observed the correlation between Ki67 expression and SUVmax,evaluated the chemotherapy effect by 18F-FDG PET/CT scan,and analyzed whether age,gender,SUVmax and Ki67 expression were the independent influence factors of chemotherapy effect.Results SUVmax was positively correlated with Ki67 expression(P<0.05),but no correlation with chemotherapy effect(P>0.05);Age,gender,SUVmax and Ki67 were not independent influencing factors of chemotherapy effect(P>0.05).Conclusion 18F-FDG PET/CT SUVmax could predict the proliferation and invasion of DLBCL cells,but there is no correlation between SUVmax and chemotherapy effect.Age,gender,SUVmax and Ki67 expression are not independent influencing factors of chemotherapy effect.

关 键 词：弥漫大B细胞淋巴瘤 18F-FDGPET/CT 标准化摄取值 KI67抗原 化疗疗效 

分 类 号：R733.4[医药卫生—肿瘤]