3-取代-噻唑-2(3H)-酮化合物的制备方法  

Preparation method for 3-substitutedthiazol-2(3H)-one

作　　者：王其林 杨江科 WANG Qi-lin;YANG Jiang-ke(School of Biology and Pharmaceutical Eegineering,Wuhan Polytechnic University,Wuhan 430023,China)

机构地区：[1]武汉轻工大学生物与制药工程学院,湖北武汉430023

出　　处：《武汉轻工大学学报》2018年第6期46-50,共5页Journal of Wuhan Polytechnic University

摘　　要：通过一种以酰基叠氮类化合物、2,5-二羟基-1,4-二噻烷类化合物为原料在溶剂存在的条件下,以40%浓硫酸为脱水剂,各种芳香取代的酰基叠氮与2,5-二羟基-1,4-二噻烷反应,以良好的收率得到3-取代-噻唑-2(3H)-酮,该反应为高效合成3-取代-噻唑-2(3H)-酮提供了一种简便的方法。A simple and convenient method for the synthesis of 3-substituted-thiazol-2(3H)-one is presented,in which the simple acyl azides and 1,4-dithiane-2,5-diol were identified as starting materials reacting in solvent,40%H 2 SO 4 as dehydrating agent.A series of aromatic acyl azides were successfully compatible with this protocol,affording the corresponding thiazol-2(3H)-one in good excellent yields,which provides a rapid and reliable approach to thiazol-2(3H)-one.

关 键 词：酰基叠氮 2 5-二羟基-1 4-二噻烷 3-取代-噻唑-2(3H)-酮 

分 类 号：R914.5[医药卫生—药物化学]