沙培林与恩度分别联合PP方案对肺腺癌合并恶性胸腔积液的疗效观察  

Curative effect of sapylin and endogenous respectively combined with PP regimen on lung adenocarcinoma with malignant pleural effusion

作　　者：曾晓媛[1] 汪砥[1] 杨红忠[1] 陈剑波 彭甘霖 周丽华[1] Zeng Xiaoyuan;Wang Di;Yang Hongzhong(Changsha central Hospital, Changsha 410004)

机构地区：[1]湖南省长沙市中心医院呼吸病诊疗中心,410004

出　　处：《中国现代医药杂志》2018年第12期1-5,共5页Modern Medicine Journal of China

基　　金：湖南省医药卫生项目(编号:B2017205)

摘　　要：目的观察沙培林与恩度分别联合PP方案对肺腺癌合并恶性胸腔积液的近远期疗效。方法将56例肺腺癌合并恶性胸腔积液患者随机平均分成两组,A组(28例)采用胸膜腔内注入沙培林并联合应用PP方案(培美曲塞+顺铂)全身化疗;B组(28例)采用胸膜腔内注入恩度并联合应用PP方案(培美曲塞+顺铂)全身化疗。观察两年,比较两组的不良反应、近期疗效及远期疗效。结果 A、B两组胸水控制短期有效率分别为92.8%、75.0%,两组比较差异有统计学意义(P<0.05);两组治疗后的KPS评分及生活质量改善均较治疗前提高,且A组较B组改善显著(P<0.05);A组生存期为(12.46±6.4)个月,优于B组的(9.11±4.98)个月(P<0.05);A组1年生存率为53.6%优于B组的25.0%(P<0.05);B组发热及胸痛不良反应发生率低于A组(P<0.05),其余副反应两组比较差异无统计学意义(P>0.05)。结论沙培林+PP方案对肺腺癌合并恶性胸腔积液有较好短期疗效,能更好地提高患者的生活质量及生存率。Objective To observe the short-term and long-term effect of sapylin and endogenous respectively combined with PP regimen on lung adenocarcinoma with malignant pleural effusion.Methods56patients with lung adenocarcinoma complicated with malignant pleural effusion were randomly divided into two groups,group A:28cases,intraperitoneal injection of sapylin combined with PP regimen(pemetrexed+cisplatin)systemic chemotherapy;group B:28cases,intraperitoneal injection of endogenous combined with PP regimen(pemetrexed+cisplatin)systemic chemotherapy.observed for two years,comparing adverse and short-term and long-term efficacy.Results The short-term effective rate of pleural fluid control in group A and B was respectively92.8%,75.0%.There was significant difference between the two groups(P<0.05).KPS score and life quality improvement of the two groups were both improved,compared with group B,group A was highly improved(P<0.05);group A survival time was(12.46±6.4)months,group B was(9.11±4.98)months,the survival rate of group A was better than that of group B(P<0.05).The one-year survival rate of the two groups was53.6%in group A and25.0%in group B,group A was better than group B(P<0.05).The fever and chest pain response in group B was lower than group A,there was significant difference between the two groups(P<0.05),the other side reactions were not significantly different(P>0.05).Conclusion Sapylin+PP regimen has better short-term effect,which can better improve quality life and survival rate of the patients with lung adenocarcinoma complicated with malignant pleural effusion.

关 键 词：沙培林 恩度 恶性胸腔积液 

分 类 号：R734.2[医药卫生—肿瘤]