帕金森病血尿酸水平的临床研究  

Clinical research of serum uric acid levels in Parkinson's disease

作　　者：何香花[1] 张为[1] 庞国防[1] 梁庆华[1] 杨泽[2] 胡才友[1] HU Xianghua;ZHANG Wei;PANG Guofang;LIANG Qinghua;YANG Ze;HU Caiyou(Department of neurology, Guangxi Zhuang Autonomous Region Jiangbin hospital, Nanning 530002;Beijing hospital, Beijing 100730,China)

机构地区：[1]广西壮族自治区江滨医院神经内科,530002 [2]北京医院,卫健委北京老年医学研究所,国家老年医学中心,卫生部老年医学重点实验室,100730

出　　处：《中国老年保健医学》2018年第6期18-21,共4页Chinese Journal of Geriatric Care

基　　金：国家自然科学基金(81061120527,81370445,81472408);卫生部公益性研究基金(201302008);国家科技部十二五支撑计划(2012BAI10B01,2015BAI06B00);广西自然科学基金重点项目“LOAD关联基因联合检测的效应分析及其分子机理研究”(项目编号:2014GXNSFDA118028);广西壮族自治区卫生厅自筹课题(课题编号:Z2013275)

摘　　要：目的分析血尿酸水平在广西帕金森病患者中的改变特征。方法选取广西壮族自治区江滨医院诊断为帕金森病的患者141例,根据Hoehn-Yahr(H-Y)分期,将帕金森病患者分为早、中、晚期组;并以我院同期保健科随机选取年龄、性别和体重匹配的141名健康体检人群为对照组,检测血尿酸。结果帕金森病组血尿酸水平显著低于对照组(P=0. 009),帕金森病组和对照组男女性血尿酸水平比较均无统计学差异(P> 0. 05);晚期帕金森病患者的血尿酸水平较早期(P=0. 001)、中期低(P <0. 001);帕金森病患者H-Y分期与血尿酸水平相比较有等级相关性(P=0. 001)。结论血尿酸水平是帕金森病患病的一个标记物,可作为帕金森病病程进展的一个生物标记物。Objective To analyzed the clinical traits of blood uric acid levels in patients with Parkinson s disease(PD).Methods A total of141patients with PD and141health check-up controls from health care department,matched with age,sex and weight,were recruited in the present study.All Participants were from Jiangbin Hospital of Guangxi Zhuang Autonomous Region.According to Hoehn-Yahr(H-Y)staging,PD patients were divided into early,middle and late stages.All participants received the detection of blood uric acid levels.Results Significantly lower serum uric acid levels were observed in PD patients compared with controls(P=0.009).There was no significant difference in blood uric acid levels between the PD group and the controls(P>0.05).The blood uric acid levels in patients with late stage PD were higher than that of early(P=0.001)and middle stage PD(P<0.001).There was an inverse correlation of serum uric acid levels with H-Y scales in PD patients(P=0.001).Conclusion Blood uric acid could be an important biomarker of PD and that the serum uric acid level could be a biomarker for the progression of PD.

关 键 词：帕金森病 血尿酸 氧化应激 

分 类 号：R742.5[医药卫生—神经病学与精神病学]