广泛期小细胞肺癌化疗前后血清神经元特异性烯醇化酶、乳酸脱氢酶、血小板联合测定的价值  

Prognostic value of neuron-specific enolase,lactate dehydroge-nase and platelet before and after chemotherapy in patients with extensive small cell lung cancer

作　　者：王文 张天棋 王红兵 Wang Wen;Zhang Tianqi;Wang Hongbing(Xuzhou Medical University, Jiangsu Xuzhou 221000, China;Department of Medical Oncology, The Affiliated Hospital ofXuzhou Medical University, Jiangsu Xuzhou 221000, China)

机构地区：[1]徐州医科大学,江苏徐州221000 [2]徐州医科大学附属医院肿瘤科,江苏徐州221000

出　　处：《现代肿瘤医学》2019年第2期240-244,共5页Journal of Modern Oncology

摘　　要：目的:通过分析广泛期小细胞肺癌(ES-SCLC)患者化疗前后乳酸脱氢酶(LDH)、血小板(PLT)和神经元特异性烯醇化酶(NSE)与生存之间的关系,旨在探讨其在ES-SCLC患者预后方面的价值。方法:回顾性分析2011年3月至2016年5月于徐州医科大学附属医院经病理学确诊的ES-SCLC患者57例,用Kaplan-Meier方法、Log-rank单因素分析和COX比例模型分析患者化疗前后LDH、PLT和NSE与生存之间的关系,P <0. 05为差异有统计学意义。结果:初诊各实验室指标联合检测在广泛期小细胞肺癌患者总生存期方面差异有统计学意义(χ~2=14. 480,P <0. 001),而2周期化疗后各指标联合检测与患者总生存期无明显相关性(χ~2=2. 841,P=0. 092)。结论:初诊血清NSE、PLT、LDH水平的联合检测可理想评估ES-SCLC患者的预后。Objective: To discuss whether neuron-specific enolase( NSE),lactate dehydroge-nase( LDH),platelet( PLT) affect the prognosis of extensive small cell lung cancer by analyzing the association between the above laboratory indicators before and after treatment and disease progression of patients. Methods: In this study,a retrospective analysis of 57 patients with ES-SCLC diagnosed by pathology at the Xuzhou Medical University Affiliated Hospital from March 2011 to May 2016 was conducted. We analysis the connection between them by Kaplan-Meier method,Log-rank test and COX proportional hazards models. Statistical significance was determined for a P value less than 0. 05. Results: Joint assessment of a number of laboratory indicators before treatment is statistically significant in the overall survival of extensive stage small cell lung cancer patients( χ~2= 14. 480,P < 0. 001),but joint assessment of those after treatment is not related to the overall survival( χ~2= 2. 841,P = 0. 092).Conclusion: Joint detection of neuron-specific enolase( NSE),lactate dehydroge-nase( LDH),platelet( PLT) before treatment is meaningful for the prognosis of extensive small cell lung cancer.

关 键 词：广泛期小细胞肺癌 神经元特异性烯醇化酶 乳酸脱氢酶 血小板 预后 

分 类 号：R734.2[医药卫生—肿瘤]