Lamin A/C在干细胞表观遗传药理学中的调控作用  

Regulation of Lamin A/C in epigenetic pharmacology of stem cells

作　　者：赵林平 余细勇 ZHAO Lin-ping;YU Xi-yong(Key Lab of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences,Guangzhou Medical University, Guangzhou511436, China)

机构地区：[1]广东省分子靶标与临床药理学重点实验室广州医科大学药学院,广东广州511436

出　　处：《中国药理学通报》2019年第1期1-4,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金重点项目(No 281330007;U1601227);广东省重大科技计划资助项目(No 2014A050503047;2015B020225006)

摘　　要：Lamin A/C是核纤层的主要组成部分,在干细胞表观遗传调控中的重要作用近年来越来越被认识。Lamin A/C不仅可以起到维持核内稳态和保护染色质的作用,同时也可以作为机械刺激细胞核内的反应器,将力学信号传导至核内,可直接或间接参与基因的转录调控。该文主要综述微环境中力学信号对干细胞Lamin A/C的调节,以及Lamin A/C的功能变化对染色体修饰、基因表达调控的影响。Lamin A/C is the main component of nuclear lamina,and its important role of epigenetic pharmacology in stem cells has been recognized in recent years.Lamin A/C has been reported to maintain the nuclear homeostasis,protect the chromatin,and act as a reactor for mechanical stimulation of the nucleus to transmit mechanical signals.Besides,Lamin A/C has been discovered to participate directly or indirectly in the transcriptional regulation of the genes.This article aims to review the regulation of Lamin A/C in stem cells by mechanical signals of microenvironment,and the effect of Lamin A/C on chromosome modification and genes regulation.

关 键 词：LAMIN A/C 核纤层 干细胞 微环境 力学信号 表观遗传 

分 类 号：R-05[医药卫生] R312