Keap1-Nrf2信号通路在肝再生中的作用及相关药物研究进展  

Role of Nrf2 signaling pathway in liver regeneration and research progress of related drugs

作　　者：白庆云 BAI Qing-yun(College of Chemistry and Bioengineering, Jiangxi Key Lab of Natural Drug Research,Yichun University, Yichun Jiangxi 336000, China)

机构地区：[1]宜春学院化学与生物工程学院,江西省天然药物活性成分研究重点实验室,江西宜春336000

出　　处：《中国药理学通报》2019年第1期20-23,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81560584);江西省自然科学基金资助项目(No 20132BAB205087);江西省教育厅科技项目(No GJJ170905)

摘　　要：肝脏在化学损伤或手术切除组织后可以再生,肝再生是一个复杂的过程,涉及多种细胞因子和多个信号通路。核因子E2相关因子2(NF-E2-related factor 2, Nrf2)是氧化还原反应敏感转录因子,在细胞抗氧化防御、氧化还原平衡、炎症、中间代谢等过程中起到调控作用,并与细胞增殖密切相关。一些报告已证实在Nrf2缺失的情况下,肝脏切除术后肝再生出现了延迟现象,由此可见Nrf2信号通路参与了肝再生的过程。该文根据已有的研究结果,综述Nrf2信号通路在肝再生过程中的作用,并对影响肝再生或肝细胞增殖的药物进行总结,以期发现更多的治疗肝脏疾病的药物,并为药物作用机制的研究提供思路。Liver can regenerate after chemical damage or partial hepatectomy.Liver regeneration is a complex process involving a variety of cytokines and multiple signal pathways.Nrf2is a sensitive transcription factor of oxidation-reduction,which plays a regulatory role in cell defense,oxidation-reduction balance,inflammation and intermediate metabolism.It is closely related to cell proliferation.Some reports have proved that liver regeneration is delayed after partial hepatectomy.Furthermore,this phenomenon is observed in the mice with absence of Nrf2.Therefore,Nrf2signaling pathway is involved in the process of liver regeneration.This article reviews the role of Nrf2signaling pathway in the process of liver regeneration according to the existing research results.We have also summarized the drugs that may affect liver regeneration or hepatocyte proliferation,hoping to find more drugs for liver diseases and provide ideas for the mechanism of the drugs.

关 键 词：KEAP1 NRF2 肝损伤 肝再生 抗氧化 促肝再生药物 

分 类 号：R-05[医药卫生] R322.47