多发性骨髓瘤预后与FISH检查的关系研究  

Relationship Between Prognosis of Multiple Myeloma and FISH Examination

作　　者：郭莉[1] 吴志敏[1] Guo Li;Wu Zhimin(Xinxiang First People's Hospital,Xinxiang Henan,453000)

机构地区：[1]新乡市第一人民医院,河南新乡453000

出　　处：《现代医用影像学》2018年第7期2252-2253,共2页Modern Medical Imageology

摘　　要：目的:探讨多发性骨髓瘤预后与FISH检查的关系。方法:选择101例多发性骨髓瘤患者作为骨髓瘤组,选择101例健康志愿供髓者作为对照组,都给予血常规分析与FISH检查,调查预后情况。结果:骨髓瘤组的中性粒细胞绝对计数与血小板计数低于对照组(P<0.05)。在骨髓瘤组中,FISH检出染色体异常30例,检出率29.7%。随访至今,生存89例,生存率为88.1%,COX回归分析显示13q14、P53缺失、IgH重排都为影响多发性骨髓瘤患者预后生存的主要独立危险因素(P<0.05)。结论:多发性骨髓瘤患者的预后比较差,FISH检查的染色体异常检出率较高。Objective:To explore the relationship between the prognosis of multiple myeloma and FISH examination.Methods:101 patients with multiple myeloma were selected as the myeloma group. 101 healthy volunteers volunteered to supply marrow as control group. All of them were given blood routine analysis and FISH examination, and the prognosis was investigated.Results:The neutrophil absolute count and platelet count in the myeloma group were lower than those in the control group (P<0.05). In myeloma group, 30 cases of chromosomal abnormalities were detected by FISH, with a detection rate of 29.7%.Up to now, 89 cases were survived and the survival rate was 88.1%. COX regression analysis showed that 13q14, P53 deletion and IgH rearrangement were the main independent risk factors affecting the prognosis of multiple myeloma patients(P<0.05).Conclusion:The prognosis of patients with multiple myeloma is relatively poor, and the rate of chromosome abnormalities detected by FISH is high.

关 键 词：多发性骨髓瘤 FISH检查 预后 

分 类 号：R733.3[医药卫生—肿瘤]