吴茱萸次碱:一种多靶点天然化合物的药理学作用研究进展  

Pharmacological Effects of Rutaecarpine as Multi-targets Nature Compound

作　　者：罗丹[1] 颜行 LUO Dan;YAN Hang(Department of Physiology,Medical School,Nanchang University;Key Provincial Laboratory ofBasic Pharmacology,School of Pharmaceutical Science,Nanchang University,Nanchang 330006 ,China)

机构地区：[1]南昌大学医学院生理学系 [2]南昌大学药学院基础药理重点实验室,南昌330006

出　　处：《天然产物研究与开发》2018年第12期2207-2213,共7页Natural Product Research and Development

基　　金：国家自然科学基金(81360493);江西省自然科学基金(20161BAB215205)

摘　　要：吴茱萸次碱是中药吴茱萸的主要有效成分,具有广泛的药理学效应,如心血管保护作用、改善脑功能、保护胃黏膜、抗炎抗氧化等。在多种疾病模型的研究发现,吴茱萸次碱可作用于辣椒素受体、环氧化酶-2、NADPH氧化酶及乙酰胆碱酯酶等多种药物靶点,从多环节缓解疾病的病理生理过程。本文对近年来吴茱萸次碱作用的靶点及药理学作用及其衍生物的构效关系进行综述,为以吴茱萸次碱为先导化合物开发多靶点药物提供依据。Rutaecarpine was one of the main bioactive ingredients isolated from Chinese herbs'Wu-Chu-Yu',and has been shown to have various biological effects such as cardiovascular protection,neuroprotection,gastric mucosal protection,and anti-inflammatory effects.Studies on multiple disease models showed rutaecarpine has a superior ability to bind various proteins,such as TRPV1,COX-2,NADPH and AChE,which prevents the progress of disease through multi-targets.This review summarize的the recent advances on the biological activity of rutaecarpine and focuse的on pharmacological targets,aiming to provide more evidence supporting its use as a lead compound to design more multi-target drugs.

关 键 词：吴茱萸次碱 多靶点 辣椒素受体 NADPH 环氧化酶-2 

分 类 号：R932[医药卫生—生药学]