宫颈腺癌患者单纯放疗与同步放化疗生存情况的比较及其预后因素分析  

Comparison of the survival situation of patients with cervical adenocarcinoma between radiotherapy and concurrent radio-chemotherapy and analysis of prognostic factors

作　　者：范治军 高翠娴 徐晓颖[1] FAN Zhijun;GAO Cuixian;XU Xiaoying(Department of Radiation Oncology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116023,Liaoning,China;Department of Gynecology,Dalian Maternity and Child Health Care Hospital,Dalian 116033,Liaoning,China)

机构地区：[1]大连医科大学附属第二医院肿瘤放疗科,辽宁大连116023 [2]大连市妇幼保健院妇科,辽宁大连116033

出　　处：《癌症进展》2018年第15期1896-1899,1910,共5页Oncology Progress

摘　　要：目的探讨中晚期宫颈腺癌患者行单纯放疗与同步放化疗的生存情况,并对预后因素进行分析。方法回顾性分析123例宫颈腺癌患者的病历资料,根据治疗方法不同将患者分为单纯放疗组(n=54)和同步放化疗组(n=69)。比较两组患者的临床特征和生存情况,并对宫颈腺癌患者预后的影响因素进行分析。结果两组患者的病理分级、国际妇产科联盟(FIGO)分期、肿瘤直径、宫旁浸润情况、盆腔淋巴结转移情况比较,差异均有统计学意义(P﹤0.05)。同步放化疗组患者的生存情况优于单纯放疗组,差异有统计学意义(P﹤0.05)。单因素分析结果显示,不同病理分级、FIGO分期、肿瘤直径、宫旁浸润情况和盆腔淋巴结转移情况宫颈腺癌患者的5年总生存率比较,差异均有统计学意义(P﹤0.01);多因素分析结果显示,病理分级为Ⅱ～Ⅲ级、FIGO分期为ⅢA～ⅣA期、肿瘤直径﹥4 cm、有宫旁浸润、有盆腔淋巴结转移均是宫颈腺癌患者预后的独立危险因素。结论接受同步放化疗治疗的中晚期宫颈腺癌患者远期生存情况优于接受单纯放疗者。Objective To compare the survival situation of patients with advanced cervical adenocarcinoma between radiotherapy and concurrent radio-chemotherapy and to analyze the prognostic factors.Method The clinical data of one hundred and twenty-three patients with cervical adenocarcinoma were analyzed retrospectively.Patients were divided into radiotherapy group(n=54)and concurrent radio-chemotherapy group(n=69).The clinical charicteristics and survival of patients in the two groups were compared and the prognostic factors of patients with cervical adenocarcinoma were analyzed.Result Pathological grading,International Federation of Gynecology and Obstetrics(FIGO)stage,tumor diameter,parametrial infiltration and pelvic lymph node metastasis of the two groups were compared,and the differences were statistically significant(P<0.05).The prognosis of patients in concurrent radio-chemotherapy group was significantly better than that of patients in the radiotherapy group(P<0.05).The results of univariate analysis showed that the 5-year overall survival rates of cervical adenocarcinoma patients with different pathological grades,FIGO stages,tumor diameters,parathyroid infiltration and pelvic lymph node metastasis were statistically significantly different(P<0.01).Multivariate analysis showed that the pathological grade ofⅡ-Ⅲ,FIGO staging ofⅢA~ⅣA,tumor>4 cm in diameter,parametrial infiltration and pelvic lymph node metastasis were all independent risk factors for the prognosis of patients with cervical adenocarcinoma.Conclusion The prognosis of patients with advanced cervical adenocarcinoma received concurrent radiochemotherapy is better than that of patients with simple radiotherapy.

关 键 词：宫颈腺癌 放疗 同步放化疗 生存分析 

分 类 号：R737.33[医药卫生—肿瘤]