核因子E2相关因子2基因-653 T/C多态性与胶质细胞瘤的相关性  

Association between-653T/C polymorphism in nuclear factor erythroid 2-related factor 2 and risk of glioma

作　　者：张跃[1] ZHAGN Yue(Department of Neurosurgery, People's Hospital of Pujiang, Pujiang 611630, China)

机构地区：[1]蒲江县人民医院神经外科,四川蒲江611630

出　　处：《中华神经外科疾病研究杂志》2018年第6期489-491,共3页Chinese Journal of Neurosurgical Disease Research

摘　　要：目的探讨我国汉族人群核因子E2相关因子2(NRF2)-653T/C多态性(rs35652124)与胶质细胞瘤的相关性。方法采用聚合酶链反应-限制性片段长度多态性技术检测116例胶质细胞瘤和185例性别和年龄匹配的对照个体NRF2基因rs35652124多态性。结果 rs35652124基因型CC在胶质细胞瘤中的频率为32. 8%,高于其在对照组中的频率21. 1%,差异具有统计学意义[CC与TT对比,χ2=5. 98,优势比(OR)=2. 34,95%可信区间(CI)=1. 18～4. 65,P=0. 014;隐性模型对比:χ2=5. 11,OR=1. 82,95%CI=1. 08～3. 08,P=0. 02]。rs35652124等位基因C在胶质细胞瘤中的频率为57. 8%,高于其在对照组中的频率47. 6%,差异具有统计学意义(χ2=5. 93,OR=1. 51,95%CI=1. 08～2. 10,P=0. 015)。结论 NRF2基因rs35652124位点多态性可能是我国汉族人群胶质细胞瘤的易感因素之一。Objective The association between-653T/C polymorphism(rs35652124)in nuclear factor erythroid2-related factor2(NRF2)and risk of glioma in China was analyzed.Methods The NRF2rs35652124polymorphism was genotyped in116patients with glioma and185gender and age-matched controls using polymerase chain reaction-restriction fragment length polymorphism technique.Results The frequency of the rs35652124CC was32.8%in patients with glioma,which was significantly higher than that in controls(21.1%)(CC vs TT:χ^2=5.98,odds ratio(OR)=2.34,95%confidence interval(CI)=1.18~4.65,P=0.014;Recessive model:χ^2=5.11,OR=1.82,95%CI=1.08~3.08,P=0.02).The frequency of the rs35652124C was57.8%in patients with glioma,which was significantly higher than that in controls(47.6%)(χ^2=5.93,OR=1.51,95%CI=1.08~2.10,P=0.015).Conclusion The NRF2rs35652124polymorphism may be a risk factor for glioma in China.

关 键 词：核因子E2相关因子2 启动子 多态性 胶质细胞瘤 

分 类 号：R737[医药卫生—肿瘤]