STAT3和VEGFR-2在胆管癌中的表达与临床病理特征的关系  

Relationship Between Expression of STAT3 and VEGFR-2 in Cholangiocarcinoma and Clinicopathological Features

作　　者：陆晓[1] 秦方方[1] 段成洲 尹治清 蒋明[1] LU Xiao;QIN Fang-fang;DUAN Cheng-zhou;YIN Zhi-qing;JIANG Ming(Department of Interventional Medicine,Anyang Cancer Hospital,Anyang,Henan,455000,China)

机构地区：[1]安阳市肿瘤医院介入科,河南安阳455000

出　　处：《临床研究》2019年第1期21-23,共3页Clinical Research

摘　　要：目的探讨检测信号转导及转录激活因子3(STAT3)、血管内皮生长因子受体2(VEGFR-2)在胆管癌组织中的表达情况,及与其临床病理特征的关系。方法选取2017年1月～2018年6月于本院住院治疗的已明确诊断为胆管癌并阻塞性黄疸并行胆道引流术同时行胆道活检术治疗的患者60例为观察组,选择同期60例非肿瘤胆管上皮组织作为对照组。应用免疫组化SP法,分别检测观察组和对照组胆道上皮组织中STAT3和VEGFR-2的表达情况,并分析其与胆管癌组织临床病理特征的关系。结果观察组STAT3、 VEGFR-2阳性率高于对照组,差异有统计学意义(P <0.01)。STAT3和VEGFR-2的表达与胆管癌的临床分期、组织分化、淋巴结转移有关(P <0.05);STAT3与VEGFR-2表达呈正相关(P <0.05)。结论胆管癌组织中STAT3与VEGFR-2的表达可一定程度反映胆管癌的发生发展。Objective To investigate the expression of signal transduction and transcriptional activator 3(STAT3)and vascular endothelial growth factor receptor 2(VEGFR-2)in cholangiocarcinoma,and their relationship with clinicopathological features.Methods Sixty patients(observation group)who were diagnosed as cholangiocarcinoma with obstructive jaundice and biliary drainage under biliary biopsy were enrolled in the Anyang Cancer Hospital from January 2017 to June 2018.A nontumor bile duct epithelial tissue was used as a control group.Immunohistochemical assay was used to detect the expression of STAT3 and VEGFR-2 in the biliary epithelial tissues from both groups,and to analyze the relationship between STAT3 and VEGFR-2 and the clinicopathological features of cholangiocarcinoma.Results The positive rates of STAT3 and VEGFR-2 in the observation group were 88.3%and 71.7%,respectively,which were significantly higher than that in the control group(P<0.01).The expression of STAT3 and VEGFR-2 was correlated with the clinical stage,tissue differentiation and lymph node metastasis of cholangiocarcinoma(P<0.05).The expression of STAT3 and VEGFR-2 was positively correlated(P<0.05).Conclusions The expression of STAT3 and VEGFR-2 in cholangiocarcinoma can reflect the development of cholangiocarcinoma to a certain extent.

关 键 词：胆管癌 STAT3 免疫组化 VEGFR-2 

分 类 号：R735.8[医药卫生—肿瘤]