血清25羟基维生素D及肿瘤标志物联合诊断乳腺恶性肿瘤的价值研究  

Application Value of Combined Detection of 25(OH) D and Tumor Markers in the Diagnosis of Malignant Breast Cancer

作　　者：桂凌 陈亚军 高玲娟[1] 曾玉 Gui Ling;Chen Yajun;Gao Lingjuan;Zeng Yu(Clinical Lab, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province, 210009, P.R. China)

机构地区：[1]南京医科大学附属妇幼保健院检验科,江苏南京210009

出　　处：《老年医学与保健》2018年第6期587-588,595,共3页Geriatrics & Health Care

基　　金：国家自然科学基金面上项目(81571437)

摘　　要：目的探讨血清25羟基维生素D [25 (OH) D]及肿瘤标志物糖类抗原153(CA153)、癌胚抗原(CEA)及糖类抗原125(CA125)联合诊断乳腺恶性肿瘤的应用价值。方法研究选取乳腺恶性肿瘤33例,乳腺良性肿瘤58例及健康体检者50例作为对照,采用酶联免疫吸附试验检测血清中25 (OH) D水平,采用化学发光法检测血清中CA153、CEA和CA125含量。结果老年组乳腺癌患者血清25 (OH) D水平(19.34±6.34)显著低于非老年组(41.42±11.31),具有统计学差异(P<0.05);25 (OH) D高水平组,其肿瘤标志物CA153(57.24±6.12)、CEA (4.32±1.85)、CA125(98.12±12.25)水平显著低于25 (OH) D低水平组(分别为71.34±13.31、5.13±1.13、102.13±14.23),具有统计学差异(P<0.01);乳腺肿瘤大体为≥5 cm乳腺肿块、低分化乳腺肿块、临床分期III-IV期的乳腺肿块、存在淋巴结转移的乳腺肿块,其血清25 (OH) D水平明显低于对应组,具有统计学差异(P<0.01),且CEA浓度显著高于其对应组分,具有统计学差异(P<0.01)。结论血清25 (OH) D与肿瘤标志物CA153、CEA、CA125联合诊断对早期乳腺癌及病情进展评估具有重要的临床应用价值。Objective To explore the clinical application value of the combined detection of serum25(OH)D,tumor marker carbohydrate antigen153(CA153),carcinoembryonic antigen(CEA)and carbohydrate antigen 125(CA125)in diagnosing malignant breast cancer.Methods 33cases with malignant breast cancer,58cases with benign breast tumor and50healthy cases were selected;Enzyme-linked immunosorbent assay(ELISA)was applied in detecting the serumlevel of 25(OH)D while chemiluminescence in detecting the serum levels of CA153,CEA and CA125.Results The serum level of25(OH)D in elderly caseswith breast tumors(19.34±6.34)was much lower than that in non-elderly cases(41.42±11.31)and the difference was of statistical significance(P<0.05);the concentrations of CA153(57.24±6.12),CEA(4.32±1.85)and CA125(98.12±12.25)in cases with high level of 25(OH)D were much lower than those in cases with low level of25(OH)D[(71.34±13.31),(5.13±1.13)and(102.13±14.23)]and the differencewas of statistical significance(P<0.01);caseswith breast tumor of lumps≥5cm,low differentiated breast lumps,clinical stageIII-IV breast lumps,lymph node metastasis of breast mass had an obviously higher level of 25(OH)Dand amuch lower concentration of CEAthan the corresponding ones(P<0.01).Conclusions The combined detection of serum level of 25(OH)D,the concentrations of CA153,CEA and CA125 is of great clinical application value in the diagnosis of early breast cancer and in the evaluation of disease progression.

关 键 词：老年 乳腺癌 1 25羟基维生素D 肿瘤标志物 

分 类 号：R737.9[医药卫生—肿瘤]