帕罗西汀和认知行为疗法治疗女性强迫症效果及其对性功能的影响  

CLINICAL EFFECT OF PAROXETINE VERSUS COGNITIVE BEHAVIORAL THERAPY IN TREATMENT OF FEMALE PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER AND THEIR INFLUENCE ON SEXUAL FUNCTION

作　　者：黄飞[1] 姜祥智[1] HUANG Fei;JIANG Xiangzhi(Department of Psychiatry,Qingdao Mental Health Center,Qingdao 266034,China)

机构地区：[1]青岛市精神卫生中心精神科,山东青岛266034

出　　处：《青岛大学学报（医学版）》2018年第6期718-720,727,共4页Journal of Qingdao University(Medical Sciences)

摘　　要：目的探讨帕罗西汀和认知行为疗法(CBT)治疗女性强迫症病人的效果及其对性功能影响。方法将49例强迫症病人随机分为帕罗西汀组(给予帕罗西汀60mg/d)和CBT组(给予CBT每周1次,每次45min,共12次)。于治疗前和治疗12周末,采用耶鲁-布朗强迫症状量表(Y-BOCS)和女性性功能指数问卷(FSFI)评估病人病情和性功能障碍。结果帕罗西汀组病人治疗后性满意度、FSFI和Y-BOCS评分低于治疗前,差异有统计学意义(t=3.196～5.905,P<0.01)。CBT组病人治疗后性欲和性高潮评分高于治疗前,差异有统计学意义(t=3.924、2.601,P<0.05);FSFI和Y-BOCS评分低于治疗前,差异有统计学意义(t=2.288、5.576,P<0.05)。结论 CBT治疗女性强迫症病人的效果与帕罗西汀相似,而对性功能的改善优于帕罗西汀。Objective To investigate the clinical effect of paroxetine versus cognitive behavioral therapy(CBT)in the treatment of female patients with obsessive-compulsive disorder(OCD)and their influence on sexual function.Methods A total of49patients with OCD were randomly divided into paroxetine group(60mg/d)and CBT group(treated with CBT for45min once a week,with12times in total).Before treatment and at the end of the12-week treatment,Yale-Brown Obsessive Compulsive Scale(Y-BOCS)and Female Sexual Function Index(FSFI)questionnaire were used to evaluate disease condition and sexual dysfunction.Results After treatment,the paroxetine group had significant reductions in sexual satisfaction,FSFI score,and Y-BOCS score(t=3.196-5.905,P<0.01);the CBT group had significant increases in the scores of sexual desire and orgasm(t=3.924and2.601,P<0.05)and significant reductions in the FSFI and Y-BOCS scores(t=2.288and5.576,P<0.05).Conclusion CBT has a similar clinical effect as paroxetine in the treatment of female patients with OCD and has a better effect in improving sexual function than paroxetine.

关 键 词：强迫性障碍 帕罗西汀 认知疗法 治疗结果 性功能障碍 

分 类 号：R749.91[医药卫生—神经病学与精神病学] R493[医药卫生—临床医学]