SNCA和GBA在帕金森病中相互作用研究进展  

Advance in the interaction between SNCA and GBA in Parkinson's disease

作　　者：郭丽丽 王咏 王莹 尚冰清 耿德勤 韩旭峰 牛海晨 GUO Li-li;WANG Yong;WANG Ying;SHANG Bing-qing;GENG De-qin;HAN Xu-feng;NIU Hai-chen(Department of Clinical Medicinethe Affiliated Hospital,Xuzhou Medical University,Xuzhou 221004,China;Department of Basic Medicinethe Affiliated Hospital,Xuzhou Medical University,Xuzhou 221004,China;Experimental Animal Centerthe Affiliated Hospital,Xuzhou Medical University,Xuzhou 221004,China;Department of Neurology,the Affiliated Hospital,Xuzhou Medical University,Xuzhou 221004,China)

机构地区：[1]徐州医科大学临床医学系,江苏徐州221004 [2]徐州医科大学附属医院神经内科,江苏徐州221004 [3]徐州医科大学实验动物中心,江苏徐州221004 [4]徐州医科大学基础医学院,江苏徐州221004

出　　处：《基础医学与临床》2019年第1期97-101,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81471330);青蓝工程(2016);国家级大学生创新创业训练计划项目(201610313006);江苏省大学生创新创业训练计划重点项目(201610313006Z)

摘　　要：帕金森病(PD)是神经系统退行性疾病,病因和发病机制尚不清楚。PD相关基因(如SNCA、GBA、LRRK2、SCARB2、LAMP3、RAB29/RAB7L1、MAPT、GAK、SREBF1和GPNMB等)突变增加散发性PD罹患率。α-突触核蛋白基因SNCA和β-葡萄糖脑苷脂酶基因GBA突变是PD遗传危险因素,但二者在PD中的相关性还有待阐明。Parkinson's disease(PD) is a neurodegenerative disease and the pathogenesis is unclear. Mutations of genes related to PD,such as SNCA,GBA,LRRK2,SCARB2,LAMP3,BAB29/RAB7L1,MAPT,GAK,SREBF1,GPNMB ,et al.,increase the morbidity of the sporadic PD. SNCA and GBA are the genetic factors of PD,and their interaction in PD is still illuminated.

关 键 词：帕金森病 SNCA基因 GBA基因 

分 类 号：R741.02[医药卫生—神经病学与精神病学]