安神解毒汤对非小细胞肺癌伴骨转移患者失眠焦虑及疼痛状态影响研究  

Study on Effect of Anshen Jiedu Decoction in Treatment of Insomnia,Anxiety and Pain in Patients of Non-Small Cell Lung Cancer with Bone Metastases

作　　者：张甫婷[1] 郭惠兰 阮健 柳好 罗宇玲[1] ZHANG Futing;GUO Huilan;RUAN Jian;LIU Hao;LUO Yuling(Nanfang Hospital Affiliated to Southern Medical Univeristy,Guangzhou 510515,Guangdong,China;Wengyuan Country People's Hospital,Shaoguan 512600,Guangdong,China;Integrated Hospital of Chinese and Western Medicine Affliated to Southern Medical Univeristy,Guangzhou,Guangdong 510515,China)

机构地区：[1]南方医科大学南方医院肿瘤内科,广东广州510515 [2]广东省翁源县人民医院药剂科,广东韶关512600 [3]南方医科大学中西医结合医院肿瘤中心,广东广州510515

出　　处：《辽宁中医杂志》2018年第11期2343-2346,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：广东省科技计划项目资助(2017ZC0077)

摘　　要：目的:探讨安神解毒汤对非小细胞肺癌(NSCLC)伴骨转移患者失眠焦虑及疼痛状态的影响。方法:前瞻性入组2015年11月—2018年1月本科收治的120例NSCLC伴骨转移患者,随机分为对照组与观察组,各60例。均接受化疗、支持治疗的综合治疗。对照组在化疗间歇期予唑来磷酸治疗,观察组加服中药汤剂安神解毒汤治疗,均持续治疗4个周期。评估心理状态(焦虑、抑郁、睡眠)、生活质量(生活质量核心量表、肺癌特异子量表),比较疼痛疗效,统计骨相关性事件(SREs)发生率。结果:与治疗前比较,两组抑郁自评量表(SDS)、焦虑自评量表(SAS)、匹兹堡睡眠质量指数量表(PSQI)评分降低(P<0.01),身体功能、角色功能、情绪功能、社会功能维度评分升高(P<0.05),气促、咳嗽、咯血症状评分降低(P<0.01);与对照组比较,观察组SDS、SAS、PSQI评分较低(P<0.01),身体功能、角色功能、情绪功能、社会功能维度评分较高(P<0.05),气促、咳嗽、咯血症状评分较低(P<0.01),疼痛缓解有效率较高(P<0.05),SREs发生率较低(P<0.01)。结论:安神解毒汤治疗NSCLC伴骨转移患者失眠焦虑及疼痛方面有较好疗效,值得临床推广。Objective:To investigate the effect of Anshen Jiedu Decoction on the treatment of insomnia,anxiety and pain in patients of non-small cell lung cancer(NSCLC)with bone metastases.Methods:Totally 120 NSCLC patients with bone metastasis from November 2015 to January 2018 were randomly divided into the control group and the observation group according to the different treatments,with 60 cases in each.All the patients were treated with chemotherapy and support therapy.Patients of the control group were treated with zoledronic acid at the interval of chemotherapy while those of the observation group were additionally treated with Anshen Jiedu Decoction.The total durations of therapy were 4 months for both groups.Main outcome measures included the psychological status(anxiety,depression,and sleep),quality of life(core scale of life quality and lung cancer specific child scale),the curative effect of pain,and the incidence of bone related events(SREs).Results:After treatment,scores of SDS(Self-rating Depression Scale),SAS(Self-rating Anxiety Scale),PSQI(Pittsburgh Sleep Quality Index)and symptom scores of breathing hard,cough and hemoptysis all decreased in both groups(P<0.01)while physical function,role function,emotional function and social function dimension score significantly increased(P<0.05).The scores of SDS SAS,PSQI and symptom scores of breathing hard,cough and hemoptysis in the observation group were lower than those in the control group(P<0.01).Compared with the control group,the observation group had higher scores of physical function,role function,emotional function and social function dimension(P<0.05),better pain relief(P<0.05),and lower incidence of SREs(P<0.01).Conclusion:Anshen Jiedu Decoction showed good efficacy on the treatment of insomnia,anxiety and pain in patients of non-small cell lung cancer with bone metastases,which is worthy of clinical promotion.

关 键 词：非小细胞肺癌 骨转移 安神解毒汤 焦虑 疼痛 

分 类 号：R734.2[医药卫生—肿瘤]