小牛血去蛋白提取物眼用凝胶对青光眼术后泪膜和舒适度的影响  

Effects of deproteinized calf blood extract eye gel on tear film and ocular comfort after glaucomatous surgery

作　　者：张恒丽[1] 唐广贤[1] 李凡[1] 闫晓伟[1] 马丽华[1] 耿玉磊[1] Zhang Hengli;Tang Guangxian;Li Fan;Yan Xiaowei;Ma Lihua;Geng Yulei(Shijiazhuang First Eye Hospital, Shijiazhuang First Hospital, Hebei 050000, China)

机构地区：[1]石家庄市第一眼科医院石家庄市第一医院青光眼科,050000

出　　处：《临床眼科杂志》2018年第6期537-541,共5页Journal of Clinical Ophthalmology

摘　　要：目的观察小牛血去蛋白提取物眼用凝胶对开角型青光眼术后泪膜和舒适度的影响。方法随机连续性选择2016年1～12月在本院行青光眼手术的开角型青光眼患者60例(84只眼)分为实验组32例(40只眼)和对照组28例(44只眼)。术后妥布霉素地塞米松滴眼液点眼,每日4次,用药4周;此外,实验组术后联合小牛血去蛋白提取物眼用凝胶点眼,每日3次,用药12周。观察两组患者各时间点Schirmer I试验、泪膜破裂时间(BUT)、荧光素染色(FL)和眼部不适症状等变化。结果术前两组患者基线资料、不适症状、泪液分泌、FL和BUT均无统计学差异(P> 0. 05)。术后2周,实验组眼部不适症状、Schirmer I、FL和BUT和对照组比较均显著改善(P<0. 05);实验组术后12周和术前比较,不适症状、Schirmer I、FL、BUT均得到持续改善(P <0. 05),和对照组比较差异有统计学意义(P <0. 01)。结论小牛血去蛋白提取物眼用凝胶能显著改善开角型青光眼患者术后眼部舒适度和泪膜稳定性,促进泪膜功能恢复,在一定程度上预防了青光眼术后干眼的发生。Objective To evaluate the efficacy of deproteinized calf blood extract eye gel on tear film and ocular comfort after glaucomatous surgery. Methods 60 cases (84 eyes) with primary open-angle glaucoma from January to December 2016 consecutively recruited were randomly divided into observed group (32 cases, 40 eyes) and control group (28 cases, 44 eyes). The patients were treated postoperatively with tobramycin dexamethasone eye drops 4 times daily for 4 weeks. In addition, the patients in observed group were also prescribed postoperatively for deproteinized calf blood extract eye gel 3 times daily for 12 weeks. The changes in Schirmer I, breakup time (BUT), fluorescein staining (FL) and ocular discomfort were observed before and after surgery. Results There were no significant differences in baseline data, discomfort, tear secretion, FL and BUT between the two groups before surgery ( P >0.05). At 2 weeks after surgery, the symptoms of ocular discomfort, Schirmer I, FL and BUT in the experimental group were significantly improved ( P <0.05). In the experimental group, the symptoms of discomfort, Schirmer I, FL and BUT were compared at 12 weeks after surgery. Continuous improvement ( P <0.05), and the difference was statistically significant ( P <0.01). Conclusions The deproteinized calf blood extract eye gel obviously improves the ocular comfort and the stability of tear film, also, it promotes the recovery of tear film function for patients with open angle glaucoma after glaucoma surgery, which prevents the ocular dryness to a certain extent.

关 键 词：小牛血去蛋白提取物眼用凝胶 开角型青光眼 青光眼术后 泪膜 眼部舒适度 

分 类 号：R779.6[医药卫生—眼科]