胃癌患者化疗期间症状群与生活质量相关性的纵向研究  

Longitudinal Study on the Correlations between Symptom Clusters and Quality of Life in Patients with Gastric Cancer during Chemotherapy

作　　者：汪丹丹[1] 郑蔚[1] 侯守超 陈丹丹[1] 史艳萍[1] WANG Dandan;ZHENG Wei;HOU Shouchao;CHEN Dandan;SHI Yanping(Department of Oncology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院肿瘤科,河南省郑州市450014

出　　处：《中国全科医学》2019年第3期284-291,共8页Chinese General Practice

基　　金：河南省科技攻关项目(172102310088)

摘　　要：背景对症状群的纵向发展变化进行研究,可以得出症状群变化规律和稳定的症状群,从而有利于延续性地管理症状。目前,尚未见有关胃癌症状群的纵向研究报道。目的纵向研究胃癌患者化疗期间症状群与生活质量的相关性,旨在为指导临床进行延续性症状管理、提高患者生活质量奠定基础。方法采用纵向调查法,选取2016年9月——2017年5月在郑州大学第二附属医院就诊的行胃癌手术治疗及术后化疗的患者为调查对象。获得患者知情同意后由研究者向其发放一般资料调查表,在患者术后拟行化疗前1 d(T1)、第3次化疗后(第3次化疗结束第2天,T2)和第6次化疗后(第6次化疗结束第2天,T3)采用中文版记忆症状评估量表(MSAS)评估患者症状,并采用对应分析提取症状群,采用中文版癌症治疗功能评价-普适性量表(FACT-G)评估患者生活质量。T1时共发放问卷228份,回收有效问卷224份,有效回收率为98.2%;T2时,失访4例,死亡1例,共发放问卷223份,回收有效问卷221份,有效回收率为99.1%;T3时,失访3例,死亡2例,共发放问卷218份,回收有效问卷214份,有效回收率为98.2%。分析症状群与生活质量之间的相关性。结果 T1时患者症状数量为28.9(27.2,30.7)个,症状发生率前3位分别为体质量下降、口干、疼痛(如腹痛、腰痛),症状严重程度得分前3位分别为难以集中注意力、身体肿胀/腹胀、手臂或腿部肿胀;T2时患者症状数量为17.8(15.7,20.4)个,症状发生率前3位分别为乏力、疼痛(如腹痛、腰痛)、咳嗽,症状严重程度得分前3位分别为乏力、出汗、疼痛(如腹痛、腰痛);T3时患者症状数量为21.8(20.7,22.9)个,症状发生率前3位分别为乏力、体质量下降、没有食欲,症状严重程度得分前3位分别为乏力、没有食欲、出汗。T1、T2时患者共有能量不足症状群、消化道症状群、身心症状群、手术相关症状群和神经症状群5个症状Background Studying the longitudinal developmental changes of the symptom cluster can obtain the pattern of symptom cluster changes and stable symptom cluster,which is conducive to the continuous management of symptoms. At present,there is no longitudinal study report on the symptom cluster of gastric cancer.Objective To longitudinally study the symptom clusters and quality of life(QOL)in patients with gastric cancer during chemotherapy in order to lay the foundation for guiding clinical management of continuous symptoms and improving patients' QOL.Methods A longitudinal study was conducted among patients who underwent gastric cancer surgery and postoperative chemotherapy at the Second Affiliated Hospital of Zhengzhou University from September 2016 to May 2017.After completing the written informed consent form,they received questionnaire surveys for collecting the general clinical data with a self-developed General Clinical Data Questionnaire,investigating the symptom clusters with the Chinese version of Memorial Symptom Assessment Scale(MSAS)on the day prior to chemotherapy(T1),on the second day following the 3rd cycle of chemotherapy(T2),and on the second day following the 6th cycle of chemotherapy(T3),and obtaining the status of QOF with the Chinese version of Functional Assessment of Cancer Therapy-General(FACT-G)at T1,T2,T3.The latter two types of surveys achieved a response rate of 98.2%(224/228)at T1,a response rate of 99.1%(221/223)at T2〔the total number(223)of participants dropped by 5 cases (4 were lost to follow up,and 1 died)compared with at T1(228)〕,and a response rate of 98.2%(214/218)at T3〔the total number(218)of participants dropped by 5 cases(3 were lost to follow up,and 2 died)compared with at T2(223)〕. The correlations between symptom clusters and QOL were analyzed.Results At T1,the average number of symptom clusters was 28.9(27.2,30.7),and the top three symptoms with the highest frequency were weight loss,dry mouth,pain(such as abdominal pain and low back pain);and the top three sympto

关 键 词：胃肿瘤 化放疗 生活质量 症状群 纵向研究 

分 类 号：R735.2[医药卫生—肿瘤]