Ⅱ～Ⅳ期胆囊癌患者行根治性切除的近远期疗效观察  

The Short-term and Long-term Outcomes of Radical Resection for Patients with Ⅱ-Ⅳ Phage Gallbladder Cancer

作　　者：白燕南[1] 吴嘉艺 洪嘉明[1] 王耀东[1] AI Yannan;WU Jiayi;HONG Jiaming(Fujian Provincial Hospital,Fuzhou 350001,China)

机构地区：[1]福建省立医院,福建福州350001

出　　处：《中外医学研究》2018年第35期1-3,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：福建省自然科学基金项目(项目编号:13171091)

摘　　要：目的:探讨Ⅱ～Ⅳ期胆囊癌行胆囊癌根治术患者的近远期疗效。方法:选取笔者所在医院2007年1月-2012年9月收治的Ⅱ～Ⅳ期胆囊癌患者95例,按照随机数字表法分为观察组和对照组,其中观察组50例,对照组45例。对照组予以腹腔镜胆囊切除术,观察组予以胆囊根治术,比较两组患者手术时间、住院时间、术中出血量、并发症发生率、平均生存期、术后第1、3、5年累积生存率及累计复发率。结果:观察组手术时间、住院时间均短于对照组,差异有统计学意义(P<0.05);观察组术中出血量少于对照组,差异有统计学意义(P<0.05)。观察组胰瘘、胆瘘、腹腔感染、腹腔出血发生率分别为4.00%、10.00%、6.00%、8.00%,对照组分别为0、13.33%、6.67%、13.33%,观察组并发症总发生率为28.00%,低于对照组的33.33%,两组并发症发生率对比,差异无统计学意义(P>0.05)。观察组中位生存期长于对照组,差异有统计学意义(P<0.05)。观察组1、3、5年生存率、5年复发率分别为72.00%、48.00%、30.00%、74.00%,对照组分别为48.89%、22.22%、4.44%、91.11%,差异均有统计学意义(P<0.05)。结论:采用胆囊根治术对Ⅱ～Ⅳ期胆囊癌患者进行治疗,有助于缩短患者手术时间及住院时间,并且能够明显延长患者的中位生存时间,提高远期生存率,降低术后复发率,值得在临床中推广。Objective:To the short-term and long-term efficacy of radical resection for patients withⅡ-Ⅳphage gallbladder cancer.Method:A total of 95 cases withⅡ-Ⅳphage gallbladder cancer from January 2007 to September 2012 in our hospital were analyzed.According to the random number table method,the patients were divided into the observation group and the control group,including 50 cases in the observation group and 45 cases in the control group.The control group received laparoscopic cholecystectomy and the observation group received gallbladder radical resection,blood loss,operating time,hospital stay,complication,the median survival time,cumulative survival rates,cumulative recurrence rates were compared.Result:The operation time and the length of hospital stay of the observation group were shorter than those of the control group(P<0.05).The blood loss in the observation group was less than that in the control group(P<0.05).The incidence of pancreatic fistula,biliary fistula,abdominal infection and abdominal hemorrhage in the observation group were 4.00%,10.00%,6.00%and 8.00%,respectively,the incidence of pancreatic fistula,biliary fistula,abdominal infection and abdominal hemorrhage in the control group were 0,13.33%,6.67%,13.33%,the total incidence of complications in the observation group(28.00%)was lower than that in the control group(33.33%),but there was on significant difference(P>0.05).The median survival time of the observation group was longer than that of the control group(P<0.05).In the observation group,the 1-,3-,5-year cumulative survival rate and 5-year cumulative recurrence rate were 72.00%,48.00%,30.00%,74.00%,and in the control group,the 1-,3-,5-year cumulative survival rate and 5-year cumulative recurrence rate were 48.89%,22.22%,4.44%,and 91.11%,respectively,there were significant differences(P<0.05).Conclusion:The radical resection of gallbladder for patients withⅡ-Ⅳphage gallbladder cancer can shorten the operation time and hospital stay of patients,reduce blood loss,and significantly ex

关 键 词：胆囊根治术 胆囊癌 近远期疗效 

分 类 号：R735.8[医药卫生—肿瘤]