超滤去除丹参滴注液高分子杂质的效果研究  

Effects of Ultrafiltration on Impurities of Salvia Miltiorrhiza Injection

作　　者：刘将 马伟 周仓 LIU Jiang;MA Wei;ZHOU Cang(Shanghai Huayuan Anhui Jinhui Pharmaceutical co.LTD,Fuyang,Anhui 236000;Traditional Chinese Medicine College,Bozhou University,Bozhou,Anhui 236800)

机构地区：[1]上海华源安徽锦辉制药有限公司,安徽阜阳236000 [2]亳州学院中药学院,安徽亳州236800

出　　处：《怀化学院学报》2018年第11期86-88,共3页Journal of Huaihua University

摘　　要：对丹参滴注液超滤前后药液中高分子物质的截留去除情况进行探索研究,用以考察丹参滴注液中存在的高分子成分及使用超滤后截留去除高分子成分的作用.通过选择适宜分子量截留值的超滤膜,得到超滤后丹参滴注液,并以蛋白质、多糖、树脂、鞣质等成分为考察指标,研究超滤去除丹参滴注液中高分子杂质的效果.研究结果表明,未能在超滤后丹参滴注液中检测出蛋白质、树脂、鞣质等无效成分.因此,通过超滤能有效截留和除去丹参滴注液中的与药效无关的高分子物质,从而提高产品质量和临床使用的安全性.The effects of ultrafiltration on the macromolecules molecular compounds of salvia miltiorrhiza injection were investigated by studying the polymeric compounds before and after the ultrafiltration of salvia miltiorrhiza injection.Protein,polysaccharide,resin,tannin and other macromolecules as the research object,by selecting the ultrafiltration membrane of suitable molecular weight retention value to study the effect of ultrafiltration on the impurities in the injection of salvia miltiorrhiza. The protein,resin,tannin and other inactive components were not detected by the corresponding detection method. Ultrafiltration can effectively interception and remove the non-effective macromolecule material and improve the safety of product quality and clinical use.

关 键 词：丹参注射液 超滤 高分子无效成分 

分 类 号：R-33[医药卫生]