普芦卡必利与伊托必利在慢性便秘患者肠道准备中的效果比较  

Comparison of the effect of prucalopride and itopride on bowel preparation in patients with chronic constipation

作　　者：纪晨光[1] 刘改芳[1] 吴婧[1] 孟霞[1] 朱新影[1] 杨亮[1] JI Chen-guang;LIU Gai-fang;WU Jing;MENG Xia;ZHU Xin-ying;YANG Liang(Department of Gastroenterology,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院消化内科,河北石家庄050051

出　　处：《河北医科大学学报》2019年第2期153-155,160,共4页Journal of Hebei Medical University

摘　　要：目的比较普芦卡必利与伊托必利联合复方聚乙二醇电解质散在结肠镜检查前肠道准备的效果。方法选取拟行结肠镜检查的慢性便秘患者160例,随机分为普芦卡必利组和伊托必利组,每组80例。普芦卡必利组检查前3d开始口服普芦卡必利2mg,1次/d,检查当日服用复方聚乙二醇电解质散;伊托必利组检查前3d开始口服伊托必利50mg,3次/d,检查当日服用复方聚乙二醇电解质散。比较2组肠道清洁程度、息肉检出率、到达回盲部时间及不良反应发生情况。结果普芦卡必利组波士顿肠道准备量表评分和息肉检出率高于伊托必利组,到达回盲部时间短于伊托必利组,差异均有统计学意义(P<0.05);2组不良反应发生率差异无统计学意义(P>0.05)。结论普芦卡必利联合复方聚乙二醇电解质散在便秘患者肠道准备中的效果优于伊托必利联合复方聚乙二醇电解质散。Objective To compare the effect of prucalopride and itopride combined with polyethylene glycol electrolyte in bowel preparation before colonoscopy.Methods Totally 160 chronic constipation patients scheduled for colonoscopy were randomly divided into prucalopride and itopride groups,80 cases in each group.Patients in prucalopride group started taking prucalopride 2 mg per day three days before colonoscopy,and taking the polyethylene glycol electrolyte on the day of colonoscopy;patients in itopride group started taking itopride 50 mg 3 times per day three days before colonoscopy,and taking the polyethylene glycol electrolyte on the day of colonoscopy.The bowel preparation quality,polyp detection rate,time of reaching the ileocecal junction and adverse reactions were compared between the two groups.Results The Boston Bowel Preparation Scale score of the bowel preparation quality and the polyp detection rate of the prucaropride group were higher than that of the itopride group,and the time of reaching the ileocecal group was shorter than that of the itopride group,there was a statistical differences in the two groups(P<0.05).There was no significant difference in the incidence rate of adverse reaction between the two groups(P>0.05).Conclusion The effect of prucalopride combined with polyethylene glycol electrolyte for colonscopy preparation is better than itopride combined with polyethylene glycol electrolyte.

关 键 词：便秘 普芦卡必利 伊托必利 结肠镜检查 

分 类 号：R574.6[医药卫生—消化系统]