Xp11.2易位/TFE3基因融合相关性肾细胞癌的CT/MRI表现  

CT/MRI features of renal carcinomas associated with Xp11.2 translocation/TFE3 gene fusions

作　　者：王璐 徐鹏举 朱明明[1] WANG Lu;XU Pengju;ZHU Mingming(Department of Radiology,Taizhou Second People’s Hospital of Jiangsu Province,Taizhou 225500,Jiangsu Province,China;Department of Radiology,Zhongshan Hospital,Fudan University;Shanghai Institute of Medical Imaging,Shanghai 200032,China)

机构地区：[1]江苏省泰州市第二人民医院放射科,江苏泰州225500 [2]复旦大学附属中山医院放射科,上海市影像医学研究所,上海200032

出　　处：《肿瘤影像学》2018年第6期480-483,共4页Oncoradiology

摘　　要：目的:探讨Xp11.2易位/TFE3基因融合相关性肾细胞癌(renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion,Xp11.2/TFE RCC)的影像学特征。方法:回顾性分析14例经手术及穿刺活检病理学证实的Xp11.2/TFERCC患者的影像学资料,分析内容包括病灶的大小、位置、形态、平扫密度或信号特征及均匀性、强化程度、强化特征、有无包膜、有无淋巴结及远处转移。结果:该研究14例患者,男女比例为4∶10,其中CT发现9例,磁共振成像(magnetic resonance imaging,MRI)发现5例。病灶大小为1.8～11.8 cm;9个病灶(64.3%)呈圆形或类圆形,5个病灶(35.7%)呈不规则形;12个病灶(85.7%)密度/信号不均匀,2个病灶(14.3%)密度/信号均匀;10个病灶(71.4%)伴出血;8个病灶(57.1%)伴有坏死或囊变;13个病灶(92.9%)强化不均匀;11个病灶(78.6%)动脉期强化程度低于肾皮质但高于肾髓质,3个病灶(21.4%)低于肾皮质和肾髓质;MRI发现的5个病灶均有包膜。结论:女性多见、中等血供、具有不均匀性和存在包膜是Xp11.2/TFE RCC常见的CT/MRI影像学特征。Objective:To investigate the imaging features of renal carcinomas associated with Xp11.2 translocation/TFE3 gene fusions(Xp11.2/TFE RCC).Methods:The imaging data of 14 patients with Xp11.2/TFE RCC confirmed by operation and biopsy were analyzed retrospectively.Image analysis included maximum size location,morphology,density or signal intensity and overall homogeneity on plain scan images,enhancement degree,enhancement pattern,presence of pseudocapsule,lymph node and distant metastasis.Results:There were 14 lesions.The ratio of male to female was 4∶10.CT found 9 lesions,and MRI found 5 lesions.The size of lesions was 1.8-11.8 cm.There were 9 lesions(64.3%)with round or oval shape,and 5 lesions(35.7%)had irregular shape.Inhomogeneous density or signal intensity was observed in 12 lesions(85.7%),and other 2 lesions(14.3%)had homogeneous density or signal intensity.Hemorrhage,necrosis or cystic degeneration was observed in 10(71.4%),8(57.1%)lesions.Inhomogeneous enhancement pattern was shown in 13 lesions(92.8%).In 11 lesions(78.6%),the enhancement degree was lower than that of the renal cortex but higher than that of the renal medulla on arterial phase,but in other 3 lesions(21.4%),the enhancement degree was lower than that of the renal cortex and renal medulla.The pseudocapsule was displayed in all 5 lesions found by MRI.Retroperitoneal lymph node and liver metastasis occurred in one case.Conclusion:The CT/MRI features of Xp11.2/TFE RCC are often characterized by the masses with moderated blood supply,heterogeneity,pseudocapsule,and more frequency in females.

关 键 词：Xp11.2易位 肾细胞癌 CT 磁共振成像 

分 类 号：R737.11[医药卫生—肿瘤]