子宫内膜癌组织LSD1、HE4、CA125及CA19-9变化及临床意义  

Changes of LSD1,HE4,CA125 and CA19-9 in Tissues of Patients with Endometrial Carcinoma and Their Clinical Significance

作　　者：崔彭华[1] 张玉娟[1] 邵雪斋[1] 王会民[2] CUI Peng-hua;ZHANG Yu-juan;SHAO Xue-zhai;WANG Hui-min(Department of Gynaecology,Chengde, Hebei 067000, China;Department of Obstetrics, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, China)

机构地区：[1]承德医学院附属医院妇科,河北承德067000 [2]承德医学院附属医院产科,河北承德067000

出　　处：《临床误诊误治》2019年第1期19-22,共4页Clinical Misdiagnosis & Mistherapy

基　　金：河北省人口和计划生育委员会科技研究计划项目(2012-A25);承德市科技支撑计划项目(2013-2044)

摘　　要：目的探讨子宫内膜癌(endometrial carcinoma,EC)癌组织赖氨酸特异性去甲基化酶1(LSD1)、人附睾蛋白4(HE4)、癌抗原(CA) 125及CA 19-9的变化及临床意义。方法选取2015年8月—2017年8月承德医学院附属医院收治的行子宫切除术的EC患者60例作为观察组,另选取同期收治的功能失调性子宫出血且行子宫内膜切除术患者60例作为对照组。检测两组患者术后切除组织中LSD1、HE4、CA125、CA19-9阳性表达情况,并分析观察组LSD1、HE4、CA125及CA19-9阳性表达与国际妇产科联盟分期、病理类型、组织学分级、肿瘤直径及年龄的关系。结果观察组术中切除组织中LSD1、HE4、CA125、CA19-9阳性表达率显著高于对照组(P<0.01)。Ⅱa、Ⅲa期EC患者癌组织中LSD1、HE4、CA125、CA19-9均阳性表达,阳性表达率均高于Ⅰa、Ⅰb期患者,比较差异有统计学意义(P<0.05);腺癌及非腺癌患者癌组织中仅有LSD1阳性表达率比较差异有统计学意义(P<0.01);高分化及中-低分化癌患者癌组织中仅有HE4阳性表达率比较差异有统计学意义(P<0.01); EC患者癌组织中LSD1、HE4、CA125、CA19-9阳性表达率与肿瘤直径及年龄无关(P> 0.05)。结论 LSD1、HE4、CA125、CA19-9在EC患者癌组织中高度表达,其阳性表达对于EC患者病情进展有重要的提示作用,检测结果可用于判断EC的恶性程度。Objective To investigate the changes of lysine specific demethylase 1(LSD1),human epididymis protein 4(HE4),carcinoma antigen(CA)125 and CA19-9 in tissues of patients with endometrial carcinoma(EC)and their clinical significance.Methods Sixty patients with EC who underwent hysterectomy in Affiliated Hospital of Chengde Medical College from August 2015 to August 2017 were enrolled as the observation group,and another 60 patients with dysfunctional uterine bleeding who underwent endometrial ablation were selected as control group.Positive expressions of LSD1 protein,HE4,CA125 and CA19-9 in removed tissues of patients in the two groups were detected.The relationship of the positive expressions of LSD1,HE4,CA125,CA19-9 in observation group to the international federation of gynecology and obstetrics(FIGO)stage,pathological type,histological grade,diameter of tumor and age were analyzed.Results The positive expression rates of LSD1,HE4,CA125 and CA19-9 in cancerous tissues of observation group were higher than those in control group(P<0.01).Those indicators were positively expressed in cancerous tissues of patients with stageⅡa andⅢa EC in the observation group,and the positive expression rates was higher than those of patients with stageⅠa andⅠb EC(P<0.05).There was significant difference in the positive expression rate of LSD1 in cancerous tissues between patients with adenocarcinoma and those with non-adenocarcinoma(P<0.01).Significant difference was found in the positive expression rate of HE4 between well-differentiated and moderately-poorly differentiated cancer tissues(P<0.01).The positive rates of LSD1,HE4,CA125 and CA19-9 in cancerous tissues of EC patients were not related to the diameter of tumor and age of patients(P>0.05).Conclusion LSD1,HE4,CA125 and CA19-9 are highly expressed in cancerous tissues of EC patients.Its positive expression has important implications for the progression of EC patients,and the detection results can be used to judge the malignancy of EC.

关 键 词：子宫内膜肿瘤 赖氨酸特异性去甲基化酶1 人附睾蛋白4 抗原 肿瘤 

分 类 号：R737.33[医药卫生—肿瘤]