国内音乐疗法对阿尔茨海默病患者干预效果的Meta分析  

Clinical Effect of Domestic Music Therapy in Patients with Alzheimer's Disease: A Meta-Analysis

作　　者：李希彤 谢静涛[1] LI Xitong;XIE Jingtao(School of Humanities and Social Sciences,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学人文社科学院,湖南长沙410208

出　　处：《湖南中医药大学学报》2019年第1期52-56,共5页Journal of Hunan University of Chinese Medicine

基　　金：湖南省中医药管理局重点课题(201613)

摘　　要：目的评价音乐疗法对阿尔茨海默病患者干预效果。方法采用计算机检索中国知网、维普、中国生物医学和万方文献数据库,检索时间为2000年1月-2018年5月,按纳入与排除标准选择文献,按照Jadad量表对文献进行质量评价,最后采用RevMan 5.3软件进行Meta分析。结果共纳入9项RCT研究,共计533人,其中实验组263人、对照组270人。其中6项研究中实验组认知功能优于对照组[WMD=0.92,95%CI(0.14～1.71),P=0.02];2项研究中实验组睡眠质量优于对照组[WMD=-1.88,95%CI(-2.44～-1.32),P<0.000 1];3项研究中实验组和对照组日常生活活动能力得分差异无统计学意义(P>0.05);2项研究中实验组和对照组神经精神量表得分差异无统计学意义(P>0.05)。结论音乐疗法能改善阿尔茨海默病患者的认知功能,增强患者的日常生活能力。Objective To evaluate the clinical effect of music therapy in patients with Alzheimer's disease.Methods A computerized search was performed in CNKI,VIP,CBM,and Wanfang Data to identify relevant articles published from January 2000 to May 2018.The literature was selected according to inclusion and exclusion criteria,and the quality of articles was assessed according to the Jadad scale.Finally,the RevMan 5.3 software was used to perform meta-analysis.Results A total of nine randomized controlled trials(RCTs)involving 533 patients(263 in the experimental group and 270 in the control group)were included.Among them,six RCTs indicated that the experimental group had better cognitive function than the control group(weighted mean difference[WMD]=0.92,95%confidence interval[CI]:0.14-1.71,P=0.02).Two RCTs suggested that the experimental group had better quality of sleep than the control group(WMD=-1.88,95%CI:-2.44 to-1.32,P<0.0 001).Three RCTs indicated there was no significant difference in the scores of activities of daily living between the experimental group and the control group(P>0.05).Two RCTs suggested that there was no significant difference in the scores of Neuropsychiatric Inventory between the experimental group and the control group(P>0.05).Conclusion Music therapy can improve the cognitive function of patients with Alzheimer's disease and enhance their activities of daily living.

关 键 词：阿尔茨海默病 音乐疗法 META分析 认知功能 日常生活活动能力 睡眠质量 神经精神量表 

分 类 号：R745.7[医药卫生—神经病学与精神病学]