丁苯酞软胶囊治疗急性脑梗死的疗效及作用机制探讨  

Therapeutic effect and mechanism of butylphthalide soft capsule on acute cerebral infarction

作　　者：徐国卫 刘欣 郭达云 常玉倩 赵敏 高兰 XU Guowei;LIU Xin;GUO Dayun;CHANG Yuqian;ZHAO Min;GAO Lan(Department of Neurology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,China)

机构地区：[1]郑州大学附属郑州中心医院神经内科,河南郑州450007

出　　处：《中国实用神经疾病杂志》2018年第21期2345-2349,共5页Chinese Journal of Practical Nervous Diseases

基　　金：河南省医学科技攻关项目(编号:201504078)

摘　　要：目的探讨丁苯酞软胶囊对急性脑梗死的疗效效果及其作用机制。方法收取临床急性脑梗死患者240例,随机分为观察组和对照组,各120例。对照组接受常规治疗,观察组接受常规+丁苯酞软胶囊治疗,200mg/次,口服,3次/d;治疗14d后统计分析血清中hs-CRP、同型半胱氨酸、纤维蛋白原及IMT水平。结果治疗组NIHSS评分明显降低,总有效率明显高于对照组,差异具有统计学意义(P<0.05)。2组治疗后血清hs-CRP、同型半胱氨酸水平均明显降低,差异具有统计学意义(P<0.05);观察组血清hs-CRP、同型半胱氨酸水平较对照组降低明显,差异具有统计学意义(P<0.05)。2组治疗后纤维蛋白原水平均降低,差异具有统计学意义(P<0.05),但2组间差异无统计学意义(P>0.05);2组治疗后IMT值无明显变化,差异无统计学意义(P>0.05)。结论丁苯酞软胶囊能特异性的降低血清中hs-CRP、同型半胱氨酸水平,达到治疗急性脑梗死的目的。Objective To investigate the effect and mechanism of butylphthalide soft capsule on acute cerebral infarction.Methods A total of 240 patients with acute cerebral infarction were enrolled and randomly assigned to the observation group and the control group,120 cases each group.The control group received routine treatment.The observation group received conventional+butylphthalide soft capsule treatment,200 mg/time,orally,3 times/d;statistical analysis of serum hs-CRP,homocysteine,fibrinogen level and IMT levels after 14 days.Results The NIHSS score of the treatment group was significantly lower,and the total effective rate was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The levels of serum hs-CRP and homocysteine in the two groups were significantly lower after treatment(P<0.05).The levels of serum hs CRP and homocysteine in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).The levels of fibrinogen decreased after treatment in the two groups(P<0.05),but the difference between the two groups was not statistically significant(P>0.05).There was no significant change in IMT after treatment,the difference was not statistically significant.Significance(P>0.05).Conclusion Butylphthalide soft capsule can specifically reduce the levels of hs CRP and homocysteine in serum to achieve the purpose of treating acute cerebral infarction.

关 键 词：急性脑梗死 丁苯酞 超敏C反应蛋白 同型半胱氨酸 纤维蛋白原 内膜-中层厚度 

分 类 号：R743.33[医药卫生—神经病学与精神病学]