尤瑞克林联合依达拉奉治疗急性脑梗死的疗效观察  

The effect observation of urinary kallidinogenase combined with edaravone in treatment of acute cerebral infarction

作　　者：张青青[1] 张苗[2] 李占武[1] ZHANG Qingqing;ZHANG Miao;LI Zhanwu(Department of Pharmacy,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China;Laboratory of Pharmacy,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]郑州大学第二附属医院药学部,河南郑州450014 [2]沈阳药科大学药学院药剂研究室,辽宁沈阳110016

出　　处：《中国实用神经疾病杂志》2018年第20期2244-2248,共5页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨尤瑞克林联合依达拉奉治疗急性脑梗死的临床疗效。方法以64例急性脑梗死患者为研究对象,随机分为对照组和实验组各32例。对照组给予依达拉奉治疗,实验组在给予依达拉奉治疗的基础上注射尤瑞克林。对比2组疗效。结果对照组总有效率为75.0%,实验组总有效率为93.7%,差异有统计学意义(P<0.05)。治疗后,2组神经功能缺损评分(NIHSS)均有明显改善(P<0.05),实验组效果明显优于对照组(P<0.05)。结论尤瑞克林和依达拉奉对急性脑梗死均有良好治疗效果,两者联合使用可显著改善患者神经功能。Objective To investigate the clinical effect of urinary kallidinogenase combined with edaravone in treatment of acute cerebral infarction.Methods 64 cases of the patients with acute cerebral infarction were divided into control group and treatment group,each of 32 cases.The control group was given edaravone for treatment,While the treatment group was treated with urinary kallidinogenase and edaravone.The efficacy was compared between the two groups of patients after 14 days of treatment.Results Comparing with the control group,the total effective rate of the treatment group was 93.7,notably improved(P<0.05).The two groups’NIHSS score had improved significantly,and the treatment group was improved much better than that of control group(P<0.05).Conclusion Both of the urinary kallidinogenase and edaravone have good curative effects to acute cerebral infarction,and when combining urinary kallidinogenase and edaravone,the NIHSS score and rehabilitation of patients could be improved significantly.

关 键 词：急性脑梗死 缺血性脑卒中 急性脑血管病 尤瑞克林 依达拉奉 溶栓 

分 类 号：R743.33[医药卫生—神经病学与精神病学]