血清三酰甘油水平与急性胰腺炎并发器官功能衰竭的相关性  

Correlation between serum triglyceride level and organ failure in patients with acute pancreatitis

作　　者：林燕 张发钦 李海涛[2] LIN Yan;ZHANG Faqin;LI Haitao(Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou 350007 Fujian, China;Fuzhou General Hospital of Nanjing Military Region)

机构地区：[1]厦门大学附属福州第二医院,福建福州350007 [2]南京军区福州总医院

出　　处：《中国民康医学》2018年第24期10-12,共3页Medical Journal of Chinese People’s Health

基　　金：福建省自然科学基金项目(项目编号2017J01321)

摘　　要：目的:分析血清三酰甘油(TG)水平与急性胰腺炎并发器官功能衰竭的相关性。方法:回顾性分析2016年1月至2017年12月216例急性胰腺炎患者的临床资料,根据入院时血清TG水平将其分为TG正常组135例和TG升高组81例,统计比较两组持续器官功能衰竭发生情况及急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分,并分析患者血清TG水平与持续器官功能衰竭、APACHEⅡ评分的相关性。结果:TG升高组持续性器官功能衰竭发生率及APACHEⅡ评分均明显高于正常组,且中度和重度升高患者明显高于轻度升高患者,重度升高患者明显高于中度升高患者,差异均有统计学意义(P<0.05);Spearman相关分析结果显示,血清TG水平与APACHEⅡ评分、并发持续性器官功能衰竭均呈显著正相关(P<0.05)。结论:血清TG水平与急性胰腺炎严重程度呈正相关,血清TG水平越高预示急性胰腺炎病情越严重、发生持续性器官功能衰竭的风险越高。Objective: To investigate correlation between serum triglyceride level and organ failure in patients with acute pancreatitis. Methods: The clinical data of 216 patients with acute pancreatitis were retrospectively analyzed. According to the serum TG level at admission, they were divided into normal group(n=135) and increased TG group(n=81). The incidence of persistent organ failure as well as the acute physiology and chronic health evaluation II(APACHE II) scores were analyzed and statistically compared. The correlations among the serum TG levels, persistent organ failure and APACHE II scores were analyzed. Results: The incidence of persistent organ failure and APACHE II scores in the increased TG group were signifi cantly higher than those in the normal group; the TG increase in the moderate and severe patients were signifi cantly higher than those with mild disease, and that of those with severe disease were signifi cantly higher than that of those with moderate disease; and the differences were statistically significant(P<0.05). Spearman correlation analysis showed that serum TG levels were significantly positively correlated with APACHE II scores and persistent organ failure(P<0.05). Conclusions: The level of serum TG is associated with the severity of acute pancreatitis. The higher serum TG level indicates the more severe acute pancreatitis and the higher risk of persistent organ failure.

关 键 词：急性胰腺炎 血清三酰甘油 持续性器官功能衰竭 

分 类 号：R576[医药卫生—消化系统]