不同分子亚型非特殊型浸润性乳腺癌超声特征  

Ultrasonographic features of different molecular subtypes of no specific type invasive breast carcinoma

作　　者：郭玉萍[1] 裴书芳[1] 刘娟娟[1] 吴丽桑[1] 肖美华[1] GUO Yuping;PEI Shufang;LIU Juanjuan;WU Lisang;XIAO Meihua(Department of Ultrasound,Guangdong Academy of Medical Sciences,Guangdong General Hospital,Guangzhou 510080,China)

机构地区：[1]广东省医学科学院广东省人民医院超声科,广东广州510080

出　　处：《中国医学影像技术》2019年第1期82-85,共4页Chinese Journal of Medical Imaging Technology

基　　金：广东省医学科学技术研究基金(A2018348)

摘　　要：目的探讨不同分子亚型非特殊型浸润性乳腺癌的超声特征。方法根据免疫组化结果,将经病理证实的193例非特殊型浸润性乳腺癌患者分Luminal A-like型(n=46)、Luminal B-like型(n=98)、HER-2过表达型(n=22)和基底样型(n=27)4种分子亚型。回顾性分析4种分子亚型乳腺癌的超声特征,包括肿块形状、边缘、方向、内部回声、后方回声、钙化、血流及肿瘤大小、病理分级及淋巴结转移情况。结果 193例非特殊型浸润性乳腺癌,4种分子亚型间,肿块大小(<2cm、2～3cm、≥3cm)和淋巴结转移(有、无)差异均无统计学意义(P均>0.05),病理分级(Ⅰ、Ⅱ、Ⅲ级)差异有统计学意义(P<0.01)。4种分子亚型间6个超声征象(形状、边缘、方向、内部回声、后方回声、钙化)差异有统计学意义(P均<0.01),血流差异无统计学意义(P=0.16)。结论不同分子亚型的非特殊类型浸润性乳腺癌超声表现有其特征性,Luminal A-like型与Luminal B-like型超声声像图表现差异较小,鉴别有一定困难。Objective To explore the ultrasonographic features of different molecular subtypes of no specific type invasive breast carcinoma.Methods According to immunohistochemical results,193 patients with no specific type invasive breast carcinoma were divided into 4molecular subtypes,i.e.Luminal A-like type (n=46),Luminal B-like type (n=98),HER-2expression type (n=22)and basal-like type (n=27).The ultrasonographic features of the 4molecular subtypes breast carcinoma were retrospectively analyzed,including the shape,edge,direction,internal echo,rear echo change,calcification,blood flow,tumor sizes,histopathological grade and lymph node metastasis.Results There was no statistically significant difference in the tumor sizes (<2cm,2—3cm,≥3cm)nor lymph node metastasis (with or without)among them (both P>0.05),but in the histopathological grade (grade Ⅰ,Ⅱ,Ⅲ),there was a statistically significant difference (P<0.01).Totally 6ultrasonographic features (shape,edge,direction,internal echo,rear echo change and calcification)had statistically significant differences among 4subtypes (all P<0.01),while the blood flow had no statistically significant difference (P=0.16).Conclusion The ultrasonographic features of different molecular subtypes of no specific type invasive breast carcinoma have certain characteristics.The difference of ultrasonographic features is limited between Luminal A-like and Luminal B-like types,which may bring difficulties for differential diagnosis.

关 键 词：乳腺肿瘤 非特殊型浸润性癌 分子分型 超声检查 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]