原发胃癌^(18)F-FDG PET/CT代谢参数与临床病理特征的相关性  

Correlation of ^(18)F-FDG PET/CT metabolic parameters and clinicopathological factors of primary gastric cancer

作　　者：周锦 张漫雪 胡秀芝 徐阳 汤泊 ZHOU Jin;ZHANG Manxue;HU Xiuzhi;XU Yang;TANG Bo(Department of Medical Imaging,Shuyang Affiliated Hospital of Nanjing University ofChinese Medicine,Suqian 223600,China)

机构地区：[1]南京中医药大学沭阳附属医院影像科,江苏宿迁223600

出　　处：《中国医学影像技术》2019年第1期95-99,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨原发胃癌18F-FDG PET/CT代谢参数与临床病理特征的相关性。方法回顾性分析我院经手术病理证实的44例胃癌患者的18F-FDG PET/CT显像特征和临床资料,记录胃癌原发灶的最大标准摄取值(SUV_(max))、平均标准摄取值(SUV_(mean))及代谢体积(MTV),并计算病灶糖酵解总量(TLG)。分别比较不同肿瘤T分期、N分期、病理分期及细胞组织分化程度组间上述代谢参数的差异,并分析上述代谢参数与临床病理特征的相关性。结果 44例原发胃癌的SUV_(max)、SUV_(mean)、MTV及TLG分别为5.81(3.45,7.77)、3.42(1.87,4.37)、14.80(9.02,25.19)cm^3及42.03(18.89,107.87)g。不同T分期胃癌原发灶的SUV_(max)、SUV_(mean)、MTV、TLG差异均无统计学意义(P均>0.05);不同N分期及病理分期胃癌原发灶的MTV、TLG差异均有统计学意义(P均<0.05),而SUV_(max)、SUV_(mean)差异均无统计学意义(P均>0.05);不同细胞组织分化程度胃癌原发灶SUV_(max)、SUV_(mean)差异有统计学意义(P均<0.05),而MTV、TLG差异无统计学意义(P均>0.05)。SUV_(max)、SUV_(mean)与肿瘤T分期及细胞组织分化程度呈中度正相关(P均<0.05),与肿瘤N分期及病理分期均无显著相关性(P均>0.05);MTV及TLG与肿瘤T分期、N分期及病理分期均呈中度正相关(P均<0.05);MTV及TLG与肿瘤细胞组织分化程度均无显著相关(P均>0.05)。结论胃癌原发灶的^(18)F-FDG PET/CT代谢参数可反映肿瘤的部分临床病理特征,有助于临床制定个体化治疗方案。Objective To investigate the correlation of metabolic parameters of 18 F-FDG PET/CT and clinicopathological factors of gastric cancer.Methods 18 F-FDG PET/CT characteristics and clinical data of histopathologically proved gastric cancer in 44 patients were reviewed retrospectively.The maximum standardized uptake value(SUV max),mean standardized uptake value(SUV mean)and metabolic tumor volume(MTV)of primary lesions were measured,and total lesion glycolysis(TLG)was calculated.The differences of the above metabolic parameters among different T-stage,N-stage,pathological stage and cell differentiated degree of tumors were compared,and the correlation of metabolic parameters and clinicopathological factors was analyzed.Results SUV max,SUV mean,MTV and TLG of 44 primary lesions was 5.81(3.45,7.77),3.42(1.87,4.37),14.80(9.02,25.19)cm^3 and 42.03(18.89,107.87)g,respectively.There was no statistical difference of SUV max,SUV mean,MTV nor TLG between different T-stage of primary lesions(all P>0.05).There were statistical differences of MTV and TLG of different N-stage and pathological stage groups(all P<0.05).There was no statistical difference of SUV max and SUV mean of different N-stage and pathological stage groups(all P>0.05).There were statistical differences of SUV max and SUV mean among different cell differentiated degrees(both P<0.05).There was no statistical difference of MTV and TLG among different cell differentiated degrees(both P>0.05).SUV max and SUV mean were positively correlated with T-stage and cell differentiated degree of tumors(all P<0.05),respectively.There was no significant correlation of SUV max,SUV mean with N-stage nor pathological stage of tumors(all P>0.05).MTV and TLG were positively correlated with T-stage,N-stage with pathological stage of tumors(all P<0.05),respectively.There was no significant correlation of MTV,TLG with pathological stage of tumors(all P>0.05).Conclusion 18 F-FDG PET/CT metabolic parameters of primary gastric cancer could reflect partial clinicopathological characterist

关 键 词：胃肿瘤 体层摄影术 发射型计算机 单光子 氟脱氧葡萄糖F18 

分 类 号：R735.2[医药卫生—肿瘤] R817.4[医药卫生—临床医学]