脑电双频指数监测丙泊酚靶控输注对腹腔镜直肠癌根治术老年患者术后认知功能的影响  

Effect of target-controlled propofol infusion with bispectral index on postoperative cognitive function in elderly patients undergoing laparoscopic resection of rectal cancer

作　　者：杨作天[1] 梁大顺[1] 廖历兴[1] 李敏[1] 吴君萍[1] 文珠仁[1] YANG Zuo-tian;LIANG Da-shun;LIAO Li-xing;LI Min;WU Jun-ping;WEN Zhu-ren(Department of Anesthesiology,Guangdong Agricultural Reclamation Center Hospital,Zhanjiang 524002,China)

机构地区：[1]广东省农垦中心医院麻醉科,广东湛江524002

出　　处：《广东医科大学学报》2018年第6期679-682,共4页Journal of Guangdong Medical University

基　　金：广东省湛江市科技计划项目(No.2017B01032)

摘　　要：目的观察脑电双频指数(BIS)监测丙泊酚靶控输注对腹腔镜直肠癌根治术老年患者术后认知功能的影响。方法 70例行腹腔镜直肠癌根治术老年患者根据BIS值(观察组)或临床经验(对照组)调整丙泊酚泵注速度,采用简易精神状态检查表(MMSE)评估认知功能,检测血清S100β蛋白水平和苏醒质量指标。结果观察组丙泊酚用量、血清S100β蛋白水平、苏醒质量指标及术后认知功能障碍(POCD)发生率均明显低于对照组(P<0.01或0.05),而MMSE评分明显高于对照组(P<0.01)。结论 BIS监测丙泊酚靶控输注可减少丙泊酚用量、POCD发生、神经系统损伤,并提高苏醒质量。Objective To investigate the effect of target-controlled propofol infusion(TCPI)with bispectral index(BIS)on postoperative cognitive function in elderly patients undergoing laparoscopic resection of rectal cancer(LRRC).Methods Seventy elderly patients undergoing LRRC were treated with TCPI based on BIS monitoring(observation group)or clinical experience(control group).The cognitive function was evaluated by Mini Mental State Examination(MMSE),and serum S100βlevel and resuscitation indexes were also measured.Results Compared with control group,propofol dosage,serum S100βlevel,resuscitation indexes and postoperative cognitive dysfunction(POCD)were decreased(P<0.01 or 0.05),while MMSE scores were increased(P<0.01)in observation group.Conclusion TCPI with BIS can reduce propofol dosage,POCD and nervous system damage,and improve the resuscitation quality in elderly patients undergoing LRRC.

关 键 词：脑电双频指数 丙泊酚 认知功能 老年人 

分 类 号：R575.5[医药卫生—消化系统]