超声造影联合异常凝血酶原对AFP阴性肝癌诊断价值的分析  

Diagnostic value of ultrasound contrast combined with protein induced by vitamin K absence or antagonist-Ⅱ in AFP-negative hepatocellular carcinoma

作　　者：王金成 周圆圆 高文祥[1] 王中阳[1] 尹明[1] WANG Jin-cheng;ZHOU Yuan-yuan;GAO Wen-xiang;WANG Zhong-yang;YIN Ming(Department of Ultrasound,Taizhou People′s Hospital,Taizhou 225300,Jiangsu,China)

机构地区：[1]泰州市人民医院超声科,江苏泰州225300

出　　处：《川北医学院学报》2018年第6期929-932,共4页Journal of North Sichuan Medical College

摘　　要：目的:探究超声造影联合异常凝血酶原(protein induced by vitamin K absence or antagonist-Ⅱ,PIVKA-Ⅱ)对甲胎蛋白阴性肝癌(AFP-negative hepatocellular carcinoma,AFP-NHCC)的诊断价值。方法:收集经病理确诊的AFP-NHCC患者128例与同期确诊的肝脏良性肿瘤患者130例。对两组患者行超声造影检查与PIVKA-Ⅱ检测,分析比较两者对AFP-NHCC单项诊断价值与联合诊断价值。结果:超声造影诊断AFP-NHCC的敏感性71. 09%,特异度86. 15%,准确性78. 68%; PIVKA-Ⅱ诊断AFP-NHCC的敏感性85. 94%,特异度83. 08%,准确性为84. 50%;联合诊断的敏感性93. 75%,特异度81. 54%,准确性高达87. 60%,优于单项检测准确性,且差异有统计学意义(P <0. 05)。结论:超声造影联合PIVKA-Ⅱ对AFP-NHCC具有较高的诊断价值,值得在临床上推广。Objective: To explore the diagnostic value of ultrasound contrast combined with protein induced by vitamin K absence or antagonist-Ⅱ( PIVKA-Ⅱ) for AFP-negative hepatocellular carcinoma( AFP-NHCC). Methods: 128 patients with AFP-NHCC confirmed by pathology and 130 patients with benign liver tumors were collected. Patients were underwent ultrasound contrast examination and PIVKA-Ⅱ detection. The diagnostic values of two methods and combined value for AFP-NHCC were analyzed and compared.Results: The sensitivity of ultrasound contrast to diagnose AFP-NHCC was 71. 09%,the specificity was 86. 15%,the accuracy was 78.68%. The sensitivity of PIVKA-Ⅱ detection was 85. 94%,the specificity was 83. 08%,the accuracy was 84. 50%. The sensitivity of the combined diagnosis was 93. 75%,the specificity was 81. 54%,the accuracy was 87. 60%,and the combined accuracy was better than that of the single test,the difference was statistically significant( P < 0. 05). Conclusion: Ultrasound contrast combined with PIVKA-Ⅱ detection is of high value to diagnose AFP-NHCC,and is worthy for clinical promotion.

关 键 词：超声造影 异常凝血酶原 AFP阴性肝癌 诊断价值 

分 类 号：R735.7[医药卫生—肿瘤]