自噬在炎症性肠病肠黏膜屏障损伤中的作用  

Role of Autophagy in Intestinal Mucosal Barrier Injury in Inflammatory Bowel Disease

作　　者：吴东升[1] 张彧[1] 陈大光 曹晖[2] WU Dongsheng;ZHANG Yu;CHEN Daguang;CAO Hui(Hunan University of Chinese Medicine,Changsha (410208);Department of Proctology,the First Hospital of Hunan University of Chinese Medicine,Changsha)

机构地区：[1]湖南中医药大学,410208 [2]湖南中医药大学第一附属医院肛肠科

出　　处：《胃肠病学》2018年第12期755-758,共4页Chinese Journal of Gastroenterology

基　　金：湖南省中医药科研计划项目(201804);湖南省卫生计生科研计划项目(C20180627);湖南中医药大学校级科研基金项目(ZYYDX201733)

摘　　要：自噬是一种细胞自我分解代谢的方式,其参与了炎症性肠病(IBD)发生、发展的病理过程。肠黏膜屏障损伤是IBD发病的重要基础。自噬可通过调节肠上皮细胞连接、参与病原体清除、调控炎症信号表达和免疫功能、干预肠黏液分泌和内质网应激(ERS)等多种途径介导IBD肠黏膜屏障损伤。本文就自噬在IBD肠黏膜屏障损伤中的作用作一综述。Autophagy is a way for cells to catabolize themselves,and is involved in the pathogenesis and development of inflammatory bowel disease( IBD). Intestinal mucosal barrier injury is an important basis in the pathogenesis of IBD.Autophagy may regulate intestinal epithelial cell junctions,participate in the removal of pathogens,modulate the expression of inflammatory signals and immune function,and interfere with the intestinal mucus secretion,endoplasmic reticulum stress( ERS) and other ways that mediate the intestinal mucosal barrier injury of IBD. This article reviewed the role of autophagy in intestinal mucosal barrier injury in IBD.

关 键 词：自噬 炎症性肠病 肠黏膜屏障 黏液分泌 内质网应激 

分 类 号：R574[医药卫生—消化系统]