月季花挥发油的提取及其β-环糊精包合物的初步研究  

Extraction of volatile oil from Rosa chinensis Jacq and primary study on the inclusion compound of β-cyclodextrin

作　　者：张敏娜[1] 王光辉[1] 丁瑞芳[1] 王利涛 ZHANG Minna;WANG Guanghui;DING Ruifang;WANG Litao(Pharmaceutical College,Jining Medical University,Shandong Rizhao 276826,China)

机构地区：[1]济宁医学院药学院,山东日照276826

出　　处：《上海医药》2019年第1期62-65,共4页Shanghai Medical & Pharmaceutical Journal

基　　金：济宁市科技发展计划项目(2015-57-66);济宁医学院科研计划项目资助课题(JY2015KJ014);济宁医学院2017年教师科研扶持基金(JY2017KJ050)

摘　　要：目的 :研究月季花挥发油的最佳提取工艺并对其β-环糊精包合物进行初步研究。方法 :采用水蒸气蒸馏法提取月季花中挥发油,以挥发油得率为指标,采用L_9(3~4)正交试验优化最佳提取工艺;采用饱和水溶液-超声法制备挥发油β-环糊精包合物并用显微镜法和红外光谱法对包合物鉴别。结果:挥发油最佳提取工艺条件为A3B1C3,即采用粗粉,加入8倍量的水,浸泡6 h,提取10 h;经显微镜法和红外光谱法分析,月季花挥发油包合前后具有明显不同的特征。结论:本提取工艺简单、可行,可为月季花挥发油新制剂的开发提供科学依据。Objective:To optimize the extraction technology of volatile oil from Rosa chinensis Jacq and to study its inclusion compound of b-cyclodextrin.Methods:Volatile oil was extracted from Rosa chinensis Jacq by steam distillation and its optimal extraction process was selected using the yield of volatile oil as the index by L 9(3^4)orthogonal test.β-cyclodextrin inclusion compound of the volatile oil was prepared by saturated aqueous solution ultrasonic method and identified by microscopy and infrared spectroscopy.Results:The optimal process for volatile oil extraction was as follows:using coarse powder,8-fold water,soaking for 6 h,extracting for 10 h.The analysis by microscopy and infrared spectroscopy showed that the inclusion of volatile oil from Rosa chinensis Jacq had distinct characteristics before and after inclusion.Conclusion:This technology is simple and feasible,can provide a scientific basis for the development of new preparation of the volatile oil from Rosa chinensis Jacq.

关 键 词：月季花 挥发油 正交试验 Β-环糊精 

分 类 号：R284.2[医药卫生—中药学]