FOLFOX6方案与DOF方案治疗晚期胃癌的临床疗效和安全性比较  

The clinical efficacy and safety of FOLFOX6 versus DOF regimens in the treatment of advanced gastric cancer

作　　者：昂冰[1] 宋敏[1] 李景[1] 周彩云[1] ANG Bing;SONG Min;LI Jing;ZHOU Caiyun(Department of Oncology,the Central Hospital of Huludao,Huludao 125000,Liaoning,China)

机构地区：[1]葫芦岛市中心医院肿瘤科,辽宁葫芦岛1250000

出　　处：《癌症进展》2019年第1期70-72,89,共4页Oncology Progress

摘　　要：目的比较奥沙利铂+亚叶酸钙+氟尿嘧啶(FOLFOX6)方案和多西他赛+奥沙利铂+氟尿嘧啶(DOF)方案治疗晚期胃癌的临床疗效和安全性。方法回顾性分析93例Ⅲ～Ⅳ期胃癌患者的病历资料,依据治疗方案的不同将患者分为FOLFOX6组(n=48)和DOF组(n=45)。比较两组患者化疗2个周期后的临床疗效,评定不良反应发生情况。结果化疗2个周期后,DOF组患者的总有效率和疾病控制率分别为33.3%(15/45)和84.4%(38/45),分别高于FOLFOX6组的18.8%(9/48)和68.8%(33/48),差异均有统计学意义(P﹤0.05)。治疗过程中,DOF组患者的消化道不良反应较FOLFOX6组严重,差异有统计学意义(Z=-2.516,P﹤0.05);两组患者骨髓抑制和外周神经炎的发生情况比较,差异均无统计学意义(P﹥0.05)。结论与应用FOLFOX6方案治疗晚期胃癌相比,应用DOF方案的疗效更好,虽然消化道不良反应发生率较高,但患者均可耐受。Objective To compare the efficacy and safety of oxaliplatin+leucovorin+fluorouracil(FOLFOX6)regimen and docetaxel+oxaliplatin+fluorouracil(DOF)regimen in the treatment of advanced gastric cancer.Method A total of 93 patients diagnosed with gastric cancer of stage III-IV were included and retrospectively analyzed.These patients were grouped by respective chemotherapy regimens as FOLFOX6 group(n=48)and DOF group(n=45).After 2 cycles of chemotherapy,the clinical efficacy was compared,and adverse reactions were evaluated.Result After 2 cycles of treatment,the overall response rate and disease control rate in DOF group were 33.3%(15/45)and 84.4%(38/45),and were higher than that in FOLFOX6 group at 18.8%(9/48)and 68.8%(33/48),respectively,with statistically significant differences observed(P<0.05).During treatment,the gastrointestinal adverse reactions was significantly more serious in the DOF group than in the FOLFOX6 group,the difference was statistically significant(Z=-2.516,P<0.05);the occurrence of myelosuppression and peripheral neuritis were similar between the two groups,showing no significant difference(P>0.05).Conclusion Compared with the application of FOLFOX6 regimen,DOF regimen is more efficacious in the treatment of advanced gastric cancer,though higher incidence of tolerable gastrointestinal adverse reactions is observed.

关 键 词：晚期胃癌 多西他赛 奥沙利铂 亚叶酸钙 氟尿嘧啶 

分 类 号：R735.2[医药卫生—肿瘤]